Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN06312.1DNA-(apurinic or apyrimidinic site) lyase; PFAM: HhH-GPD domain; 8-oxoguanine DNA glycosylase, N-terminal; KEGG: hvo:HVO_1681 DNA N-glycosylase; SMART: HhH-GPD domain. (335 aa)    
Predicted Functional Partners:
AEN04514.1
Protein of unknown function DUF555; PFAM: Uncharacterised protein family UPF0212; KEGG: htu:Htur_2443 protein of unknown function DUF555.
       0.730
AEN06311.1
PFAM: Mechanosensitive ion channel MscS; KEGG: hla:Hlac_1508 MscS mechanosensitive ion channel.
       0.580
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
   
 
 0.570
nfo
Endonuclease 4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
   
 
 0.512
dbh
DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.
  
 
 0.511
uvrC
UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
  
  
 0.504
AEN04767.1
ERCC4 domain protein; KEGG: hbo:Hbor_02260 ERCC4-like helicase; PFAM: ERCC4 domain; DNA/RNA helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helix-hairpin-helix motif; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; Helix-hairpin-helix DNA-binding motif, class 1.
    
   0.495
AEN06310.1
Hypothetical protein.
       0.467
AEN05056.1
KEGG: nph:NP1508A family B DNA-directed DNA polymerase; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; Hedgehog/intein hint, N-terminal.
  
 
 
 0.465
AEN05999.1
Acylphosphatase; KEGG: nph:NP3750A acylphosphatase; HAMAP: Acylphosphatase; PFAM: Acylphosphatase-like.
       0.457
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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