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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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AEN06363.1Nucleoside-triphosphatase; KEGG: hbo:Hbor_04980 ditpase; PFAM: Ham1-like protein. (207 aa)    
Predicted Functional Partners:
AEN06365.1
O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.
 
   
 0.955
guaAB
GMP synthase (glutamine-hydrolyzing) subunit B; Catalyzes the synthesis of GMP from XMP.
 
 
 0.953
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 0.946
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
  
 0.936
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.935
guaAA
GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP.
 
 
 0.926
AEN05864.1
5'-Nucleotidase domain-containing protein; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; KEGG: hbo:Hbor_11400 5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase.
 
 
 0.918
AEN06109.1
Glutamine amidotransferase class-I; KEGG: hbo:Hbor_27060 GMP synthase family protein; manually curated; PFAM: Glutamine amidotransferase class-I, C-terminal.
  
 
 0.908
AEN06865.1
PFAM: Glutamine amidotransferase class-I, C-terminal; KEGG: hla:Hlac_0721 glutamine amidotransferase class-I.
  
 
 0.908
AEN06879.1
Protein of unknown function DUF84; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
     
 0.908
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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