Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN06377.1KEGG: hla:Hlac_1958 AAA ATPase central domain protein; PFAM: ATPase, AAA-type, core; SMART: ATPase, AAA+ type, core; Belongs to the AAA ATPase family. (440 aa)    
Predicted Functional Partners:
AEN06328.1
SMART: ATPase, AAA+ type, core; TIGRFAM: 26S proteasome subunit P45; KEGG: hbo:Hbor_05530 proteasome-activating nucleotidase; PFAM: ATPase, AAA-type, core; Belongs to the AAA ATPase family.
 
 
0.913
pan
Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...]
 
 
0.911
AEN06375.1
KEGG: hvo:HVO_1905 ATP-binding protein.
 
     0.855
AEN07243.1
Acylaminoacyl-peptidase; KEGG: gct:GC56T3_2594 peptidase S9 prolyl oligopeptidase active site domain protein.
  
 0.780
AEN06962.1
PFAM: Histone deacetylase superfamily; KEGG: hvo:HVO_0522 HdaI-type histone deacetylase.
   
 0.770
AEN06118.1
KEGG: hbo:Hbor_10400 LSU ribosomal protein l32e; PFAM: Ribosomal protein L32e; SMART: Helix-hairpin-helix DNA-binding motif, class 1.
  
 0.769
map
Methionine aminopeptidase, type II; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
 
 0.722
AEN07059.1
PFAM: Nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: hvo:HVO_0292 replication protein A.
 
 
 0.719
AEN06575.1
PFAM: GTP-binding protein, HSR1-related; KEGG: hla:Hlac_2746 GTP-binding protein HSR1-related.
 
 
 0.707
AEN06391.1
Small GTP-binding protein; KEGG: hbo:Hbor_05240 GTPase; TIGRFAM: Small GTP-binding protein; PFAM: Nucleolar GTP-binding 1.
  
 0.680
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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