Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEN06425.1TIGRFAM: Methionine sulphoxide reductase B; KEGG: hvo:HVO_2234 methionine-R-sulfoxide reductase; PFAM: Methionine sulphoxide reductase B. (131 aa)    
Predicted Functional Partners:
msrA
Peptide methionine sulfoxide reductase msrA; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
 
 0.989
grpE
Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
   
 
 0.591
AEN05206.1
PFAM: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; KEGG: hla:Hlac_1351 alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen.
   
 0.487
AEN05964.1
Thioredoxin domain-containing protein; PFAM: Thioredoxin domain; KEGG: hvo:HVO_2786 thioredoxin.
   
 0.487
AEN06915.1
Thioredoxin domain-containing protein; PFAM: Thioredoxin domain; KEGG: hbo:Hbor_27560 thioredoxin domain-containing protein.
   
 0.487
AEN07141.1
Thioredoxin; KEGG: hbo:Hbor_15610 thioredoxin.
   
 0.487
AEN05641.1
KEGG: hje:HacjB3_08880 succinate dehydrogenase, cytochrome b556 subunit; TIGRFAM: Succinate dehydrogenase, cytochrome b556 subunit; PFAM: Succinate dehydrogenase, cytochrome b subunit.
  
  
 0.480
AEN05640.1
KEGG: hbo:Hbor_12890 succinate dehydrogenase subunit D.
  
    0.477
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
     
 0.463
AEN06424.1
Phosphoglycerate dehydrogenase; KEGG: htu:Htur_2328 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region.
       0.463
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.