STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEN06467.1PFAM: Amidohydrolase 3; KEGG: hbo:Hbor_10020 tim-barrel fold metal-dependent hydrolase. (514 aa)    
Predicted Functional Partners:
AEN06468.1
TIGRFAM: Hydroxymethylglutaryl-CoA reductase, class I, catalytic; KEGG: hvo:HVO_2583 hydroxymethylglutaryl-CoA reductase (NADPH); PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic; Belongs to the HMG-CoA reductase family.
       0.572
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
     
  0.539
AEN06455.1
PFAM: FxsA cytoplasmic membrane protein; KEGG: hvo:HVO_2351 FxsA-like protein.
  
  
 0.524
AEN06466.1
KEGG: hla:Hlac_0311 sec-independent protein translocase component TatA.
       0.459
pyrF
PFAM: Orotidine 5'-phosphate decarboxylase, core; TIGRFAM: Orotidine 5'-phosphate decarboxylase, subfamily 2, core; HAMAP: Orotidine 5'-phosphate decarboxylase; KEGG: hut:Huta_0923 orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily.
       0.410
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.