STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEN06468.1TIGRFAM: Hydroxymethylglutaryl-CoA reductase, class I, catalytic; KEGG: hvo:HVO_2583 hydroxymethylglutaryl-CoA reductase (NADPH); PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic; Belongs to the HMG-CoA reductase family. (409 aa)    
Predicted Functional Partners:
AEN07149.1
PFAM: Protein of unknown function DUF35; KEGG: nph:NP2608A hydroxymethylglutaryl-CoA synthase 1.
 
 
 0.997
AEN07279.1
KEGG: hbo:Hbor_08530 hydroxymethylglutaryl-CoA synthase; PFAM: Hydroxymethylglutaryl-coenzyme A synthase, N-terminal; Hydroxymethylglutaryl-coenzyme A synthase C-terminal.
 
 
 0.992
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
 
 0.980
AEN06284.1
SMART: DNA topoisomerase, type IIA, subunit B or N-terminal; ATP-binding region, ATPase-like; Hedgehog/intein hint, N-terminal; Hedgehog/intein hint domain, C-terminal; TIGRFAM: DNA gyrase, subunit B; Intein splicing site; KEGG: syn:sll2005 DNA gyrase B subunit; PFAM: DNA topoisomerase, type IIA, subunit B, region 2; ATP-binding region, ATPase-like; Toprim domain; DNA topoisomerase, type IIA, subunit B, C-terminal.
     
 0.791
AEN05133.1
PFAM: GHMP kinase; GHMP kinase, C-terminal; KEGG: hla:Hlac_1434 GHMP kinase.
 
  
 0.741
idi
Isopentenyl-diphosphate Delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
  
  
 0.694
pyrF
PFAM: Orotidine 5'-phosphate decarboxylase, core; TIGRFAM: Orotidine 5'-phosphate decarboxylase, subfamily 2, core; HAMAP: Orotidine 5'-phosphate decarboxylase; KEGG: hut:Huta_0923 orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily.
     
 0.654
AEN06467.1
PFAM: Amidohydrolase 3; KEGG: hbo:Hbor_10020 tim-barrel fold metal-dependent hydrolase.
       0.572
AEN05562.1
PFAM: Polyprenyl synthetase; KEGG: hbo:Hbor_11930 geranylgeranyl-diphosphate synthase; farnesyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family.
 
 
 0.570
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
     
 0.539
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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