Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN06484.1TIGRFAM: Dihydrolipoamide dehydrogenase; KEGG: hbo:Hbor_02940 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. (474 aa)    
Predicted Functional Partners:
AEN06482.1
Pyruvate dehydrogenase (acetyl-transferring); KEGG: hla:Hlac_0140 transketolase central region; PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal.
 
 0.997
AEN06483.1
Dihydrolipoyllysine-residue acetyltransferase; KEGG: hla:Hlac_0141 branched-chain alpha-keto acid dehydrogenase subunit E2; PFAM: 2-oxoacid dehydrogenase acyltransferase, catalytic domain; Biotin/lipoyl attachment; E3 binding.
 0.997
AEN06481.1
TIGRFAM: Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit subgroup x; KEGG: hla:Hlac_0139 pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; PFAM: Dehydrogenase, E1 component.
 
 
 0.994
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.964
AEN05768.1
PFAM: Glycine cleavage system P-protein, N-terminal; KEGG: hbo:Hbor_08350 glycine dehydrogenase (decarboxylating) subunit beta.
  
 0.957
AEN04662.1
TIGRFAM: Folate-binding, YgfZ; KEGG: hbo:Hbor_27940 aminomethyltransferase; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel.
  
 0.948
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
  
 0.948
AEN05767.1
KEGG: hbo:Hbor_08360 glycine dehydrogenase (decarboxylating) alpha subunit; PFAM: Glycine cleavage system P-protein, N-terminal.
  
 
 0.938
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.927
folD
Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.918
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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