Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (723 aa)    
Predicted Functional Partners:
AEN06547.1
PFAM: Ferredoxin; KEGG: hje:HacjB3_14770 ferredoxin.
      0.924
uvrC
UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 
   
 0.847
AEN05313.1
TIGRFAM: Nop2p; KEGG: hbo:Hbor_16210 nol1/nop2/sun family RNA methylase; PFAM: Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
 
    0.750
AEN06003.1
ABC-type transporter, integral membrane subunit; PFAM: Bacterial inner-membrane translocator; KEGG: hvo:HVO_1398 putative sugar ABC transporter permease.
  
    0.682
AEN04983.1
PFAM: DNA helicase, UvrD/REP type; KEGG: hmu:Hmuk_3309 ATP-dependent exoDNAse (exonuclease V) beta subunit-like protein (contains helicase and exonuclease domains).
 
  
 0.654
AEN07262.1
PFAM: DNA helicase, UvrD/REP type; KEGG: hla:Hlac_0203 UvrD/REP helicase.
 
  
 0.648
AEN06545.1
KEGG: htu:Htur_2384 beta-lactamase domain protein.
       0.628
mutL
DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
  
  
 0.612
AEN06284.1
SMART: DNA topoisomerase, type IIA, subunit B or N-terminal; ATP-binding region, ATPase-like; Hedgehog/intein hint, N-terminal; Hedgehog/intein hint domain, C-terminal; TIGRFAM: DNA gyrase, subunit B; Intein splicing site; KEGG: syn:sll2005 DNA gyrase B subunit; PFAM: DNA topoisomerase, type IIA, subunit B, region 2; ATP-binding region, ATPase-like; Toprim domain; DNA topoisomerase, type IIA, subunit B, C-terminal.
 
  
 0.593
rad50
DNA double-strand break repair rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex. Belongs to the SMC family. RAD50 subfamily.
     
 0.588
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.