Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
guaAAGMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP. (184 aa)    
Predicted Functional Partners:
guaAB
GMP synthase (glutamine-hydrolyzing) subunit B; Catalyzes the synthesis of GMP from XMP.
  
 0.998
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.980
AEN06363.1
Nucleoside-triphosphatase; KEGG: hbo:Hbor_04980 ditpase; PFAM: Ham1-like protein.
 
 
 0.926
AEN06865.1
PFAM: Glutamine amidotransferase class-I, C-terminal; KEGG: hla:Hlac_0721 glutamine amidotransferase class-I.
 
  
 
0.918
surE
Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.916
AEN06109.1
Glutamine amidotransferase class-I; KEGG: hbo:Hbor_27060 GMP synthase family protein; manually curated; PFAM: Glutamine amidotransferase class-I, C-terminal.
 
  
 
0.908
AEN05864.1
5'-Nucleotidase domain-containing protein; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; KEGG: hbo:Hbor_11400 5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase.
    
 0.903
AEN06703.1
PFAM: Protein of unknown function DUF2070, membrane; KEGG: hbo:Hbor_25610 membrane protein.
       0.848
map
Methionine aminopeptidase, type II; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
  
    0.820
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
  
 0.766
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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