Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN06915.1Thioredoxin domain-containing protein; PFAM: Thioredoxin domain; KEGG: hbo:Hbor_27560 thioredoxin domain-containing protein. (88 aa)    
Predicted Functional Partners:
AEN06916.1
KEGG: hut:Huta_0325 preprotein translocase subunit SecG.
       0.850
dnaK
Chaperone protein dnaK; Acts as a chaperone.
  
 0.779
AEN05667.1
KEGG: nph:NP3056A peptidylprolyl isomerase; PFAM: Peptidyl-prolyl cis-trans isomerase, cyclophilin-type.
   
 0.746
pdxT
Glutamine amidotransferase subunit pdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
       0.702
hisE
TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphatase; KEGG: nph:NP0470A phosphoribosyl-ATP pyrophosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase.
       0.701
msrA
Peptide methionine sulfoxide reductase msrA; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
   
 0.700
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
 
 
 0.695
rpl40e
KEGG: hut:Huta_1320 50S ribosomal protein L40e; HAMAP: 50S ribosomal protein L40e; PFAM: Ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
  
 0.692
AEN06012.1
Heat shock protein DnaJ domain protein; KEGG: hbo:Hbor_22210 DnaJ-class molecular chaperone with C-terminal zn finger domain; PFAM: Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal.
 
 
 0.691
AEN04538.1
Thioredoxin-disulfide reductase; KEGG: hla:Hlac_0323 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
 
 
 0.584
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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