Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN06976.1Porphobilinogen deaminase; TIGRFAM: Tetrapyrrole biosynthesis, hydroxymethylbilane synthase; KEGG: hvo:HVO_0078 porphobilinogen deaminase; PFAM: Tetrapyrrole biosynthesis, hydroxymethylbilane synthase. (382 aa)    
Predicted Functional Partners:
AEN06974.1
Porphobilinogen synthase; KEGG: hmu:Hmuk_0925 delta-aminolevulinic acid dehydratase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; Belongs to the ALAD family.
 
 0.999
AEN06977.1
PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; KEGG: hvo:HVO_0076 uroporphyrinogen-III synthase.
 
 0.999
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.979
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.963
hemL
HAMAP: Glutamate-1-semialdehyde 2,1-aminomutase; KEGG: htu:Htur_0185 aminotransferase class-III; PFAM: Aminotransferase class-III.
 
  
 0.941
AEN06346.1
PFAM: Chlorite dismutase; Antibiotic biosynthesis monooxygenase; KEGG: hbo:Hbor_04740 hypothetical protein.
 
   
 0.905
AEN06745.1
Glutamate-1-semialdehyde 2,1-aminomutase; KEGG: nmg:Nmag_3847 aminotransferase class-III; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
  
 0.858
AEN07014.1
Glutamate-1-semialdehyde 2,1-aminomutase; KEGG: nmg:Nmag_3749 aminotransferase class-III; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
  
 0.786
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.642
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
     
 0.544
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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