Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN06981.1SMART: ATPase, AAA+ type, core; TIGRFAM: Peptidase S16, archaeal lon homologues; KEGG: hwa:HQ1163A ATP-dependent protease Lon; PFAM: Peptidase S16, lon C-terminal; Magnesium chelatase, ChlI subunit; Belongs to the peptidase S16 family. (713 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein dnaK; Acts as a chaperone.
 
 0.929
AEN06982.1
PFAM: Abortive infection protein; KEGG: hje:HacjB3_14285 abortive infection protein.
       0.907
AEN06660.1
Thermosome; KEGG: hla:Hlac_2662 thermosome; TIGRFAM: Thermosome, archaeal; PFAM: Chaperonin Cpn60/TCP-1.
  
 0.883
grpE
Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
  
 0.871
AEN06875.1
Thermosome; Manually curated; TIGRFAM: Thermosome, archaeal; KEGG: htu:Htur_3025 thermosome; PFAM: Chaperonin Cpn60/TCP-1.
  
 0.865
AEN06980.1
PFAM: Cytidylyltransferase; TIGRFAM: Nicotinamide-nucleotide adenylyltransferase, archaeal type; Cytidyltransferase-related; HAMAP: Nicotinamide-nucleotide adenylyltransferase, archaeal type; KEGG: hla:Hlac_1037 nicotinamide-nucleotide adenylyltransferase.
 
     0.865
ileS
Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
  
 
 0.859
AEN05954.1
KEGG: hbo:Hbor_02300 malate dehydrogenase (NAD); PFAM: Lactate/malate dehydrogenase; Belongs to the LDH/MDH superfamily.
  
 0.843
rps2
Ribosomal protein S2; KEGG: hbo:Hbor_12460 SSU ribosomal protein s2p; TIGRFAM: Ribosomal protein S2, eukaryotic/archaeal; PFAM: Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family.
  
 0.825
AEN05617.1
KEGG: hma:rrnAC2158 aconitate hydratase; TIGRFAM: Aconitase, putative; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Aconitase A/isopropylmalate dehydratase small subunit, swivel.
   
 
 0.798
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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