LOC106154800 protein (Lingula anatina) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

LOC106154800

Protein transport protein Sec31A-like. (1860 aa)

Predicted Functional Partners:

LOC106176654

0.999

LOC106181957

0.999

LOC106181958

0.999

LOC106172041

0.998

LOC106157605

0.995

LOC106172942

0.988

LOC106178153

0.956

LOC106154623

0.930

LOC106177059

0.930

LOC106169105

0.899

Your Current Organism:

Lingula anatina

NCBI taxonomy Id: 7574
Other names: L. anatina, Lingula lingua, Lingula unguis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106154623	LOC106154800	A0A1S3HG74	A0A1S3HF97	Protein transport protein sec16.	Protein transport protein Sec31A-like.	0.930
LOC106154623	LOC106157605	A0A1S3HG74	A0A1S3HRV5	Protein transport protein sec16.	Protein transport protein Sec24C isoform X1.	0.969
LOC106154623	LOC106169105	A0A1S3HG74	A0A1S3J256	Protein transport protein sec16.	Protein TFG.	0.818
LOC106154623	LOC106172041	A0A1S3HG74	A0A1S3JCE9	Protein transport protein sec16.	Protein SEC13 homolog; Belongs to the WD repeat SEC13 family.	0.952
LOC106154623	LOC106172942	A0A1S3HG74	A0A1S3JG57	Protein transport protein sec16.	Protein SEC13 homolog; Belongs to the WD repeat SEC13 family.	0.952
LOC106154623	LOC106176654	A0A1S3HG74	A0A1S3JX15	Protein transport protein sec16.	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	0.977
LOC106154623	LOC106178153	A0A1S3HG74	A0A1S3K210	Protein transport protein sec16.	Uncharacterized protein LOC106178153.	0.910
LOC106154623	LOC106181957	A0A1S3HG74	A0A1S3KHK0	Protein transport protein sec16.	GTP-binding protein SAR1 isoform X1; Belongs to the small GTPase superfamily. SAR1 family.	0.917
LOC106154623	LOC106181958	A0A1S3HG74	A0A1S3KIE7	Protein transport protein sec16.	Protein transport protein Sec24A.	0.976
LOC106154800	LOC106154623	A0A1S3HF97	A0A1S3HG74	Protein transport protein Sec31A-like.	Protein transport protein sec16.	0.930
LOC106154800	LOC106157605	A0A1S3HF97	A0A1S3HRV5	Protein transport protein Sec31A-like.	Protein transport protein Sec24C isoform X1.	0.995
LOC106154800	LOC106169105	A0A1S3HF97	A0A1S3J256	Protein transport protein Sec31A-like.	Protein TFG.	0.899
LOC106154800	LOC106172041	A0A1S3HF97	A0A1S3JCE9	Protein transport protein Sec31A-like.	Protein SEC13 homolog; Belongs to the WD repeat SEC13 family.	0.998
LOC106154800	LOC106172942	A0A1S3HF97	A0A1S3JG57	Protein transport protein Sec31A-like.	Protein SEC13 homolog; Belongs to the WD repeat SEC13 family.	0.988
LOC106154800	LOC106176654	A0A1S3HF97	A0A1S3JX15	Protein transport protein Sec31A-like.	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	0.999
LOC106154800	LOC106177059	A0A1S3HF97	A0A1S3JXM2	Protein transport protein Sec31A-like.	Protein transport protein sec16.	0.930
LOC106154800	LOC106178153	A0A1S3HF97	A0A1S3K210	Protein transport protein Sec31A-like.	Uncharacterized protein LOC106178153.	0.956
LOC106154800	LOC106181957	A0A1S3HF97	A0A1S3KHK0	Protein transport protein Sec31A-like.	GTP-binding protein SAR1 isoform X1; Belongs to the small GTPase superfamily. SAR1 family.	0.999
LOC106154800	LOC106181958	A0A1S3HF97	A0A1S3KIE7	Protein transport protein Sec31A-like.	Protein transport protein Sec24A.	0.999
LOC106157605	LOC106154623	A0A1S3HRV5	A0A1S3HG74	Protein transport protein Sec24C isoform X1.	Protein transport protein sec16.	0.969

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

92

PPI enrichment p-value:

0.665

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016989

Sigma factor antagonist activity

3 of 5

2.41

1.96

0.00021

GO:0015343

Siderophore transmembrane transporter activity

3 of 13

2.0

1.56

0.00085

GO:0060089

Molecular transducer activity

5 of 63

1.53

0.00019

GO:0031992

Energy transducer activity

2 of 2

2.63

1.31

0.0040

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031224

Intrinsic component of membrane

10 of 1169

0.56

0.45

0.0012

GO:0016021

Integral component of membrane

9 of 1162

0.52

0.39

0.0059

GO:0016020

Membrane

11 of 1689

0.45

0.37

0.0012

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36618666

(2022) Responses of the bacterial community of tobacco phyllosphere to summer climate and wildfire disease.

2 of 2

2.63

1.3

0.0042

PMID:36677491

(2023) Sphingomonas sediminicola Is an Endosymbiotic Bacterium Able to Induce the Formation of Root Nodules in Pea (Pisum sativum L.) and to Enhance Plant Biomass Production.

3 of 17

1.88

1.27

0.0030

PMID:24319357

(2013) Engineering rhizobial bioinoculants: a strategy to improve iron nutrition.

2 of 12

1.85

0.72

0.0421

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:979

Mixed, incl. Protein insertion into membrane, and Energy transducer activity

6 of 20

2.11

3.76

7.50e-09

CL:981

Mixed, incl. Energy transducer activity, and Biopolymer transport protein ExbD/TolR

5 of 12

2.25

3.51

7.98e-08

CL:995

Mixed, incl. Energy transducer activity, and Biopolymer transport protein ExbD/TolR

4 of 5

2.54

3.3

5.52e-07

CL:5671

FecR protein, and TonB-dependent siderophore receptor

4 of 10

2.23

2.76

3.49e-06

CL:5675

FecR protein, and Secretin/TonB, short N-terminal domain

3 of 5

2.41

2.2

7.24e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005887

Integral component of plasma membrane

4 of 87

1.29

0.81

0.0125

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16220

Domain of unknown function (DUF4880)

3 of 3

2.63

2.12

0.00012

PF04773

FecR protein

3 of 3

2.63

2.12

0.00012

PF03544

Gram-negative bacterial TonB protein C-terminal

2 of 3

2.46

1.08

0.0107

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR032623

FecR, N-terminal

3 of 3

2.63

1.9

0.00032

IPR012373

Fe(2+)-dicitrate sensor, transmembrane component

3 of 3

2.63

1.9

0.00032

IPR006860

FecR protein

3 of 3

2.63

1.9

0.00032

IPR006260

TonB/TolA, C-terminal

2 of 3

2.46

0.92

0.0213

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