LOC106156669 protein (Lingula anatina) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

LOC106156669

PAX3- and PAX7-binding protein 1. (856 aa)

Predicted Functional Partners:

LOC106174844

0.899

LOC106179977

0.892

LOC106170224

0.754

LOC106178645

0.716

LOC112042071

0.670

LOC106174039

0.670

LOC106174191

0.631

LOC106151197

0.628

LOC106168771

0.588

LOC106170598

0.572

Your Current Organism:

Lingula anatina

NCBI taxonomy Id: 7574
Other names: L. anatina, Lingula lingua, Lingula unguis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106151197	LOC106156669	A0A1S3H179	A0A1S3HN87	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	PAX3- and PAX7-binding protein 1.	0.628
LOC106151197	LOC106168771	A0A1S3H179	A0A1S3IYW6	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	U5 small nuclear ribonucleoprotein 200 kDa helicase.	0.942
LOC106151197	LOC106170598	A0A1S3H179	A0A1S3J6F6	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	pre-mRNA-processing-splicing factor 8 isoform X2.	0.914
LOC106156669	LOC106151197	A0A1S3HN87	A0A1S3H179	PAX3- and PAX7-binding protein 1.	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.628
LOC106156669	LOC106168771	A0A1S3HN87	A0A1S3IYW6	PAX3- and PAX7-binding protein 1.	U5 small nuclear ribonucleoprotein 200 kDa helicase.	0.588
LOC106156669	LOC106170224	A0A1S3HN87	A0A1S3J5C2	PAX3- and PAX7-binding protein 1.	pre-mRNA-splicing factor SYF2.	0.754
LOC106156669	LOC106170598	A0A1S3HN87	A0A1S3J6F6	PAX3- and PAX7-binding protein 1.	pre-mRNA-processing-splicing factor 8 isoform X2.	0.572
LOC106156669	LOC106174039	A0A1S3HN87	A0A2R2MT95	PAX3- and PAX7-binding protein 1.	pre-mRNA-processing factor 17.	0.670
LOC106156669	LOC106174191	A0A1S3HN87	A0A1S3JMH6	PAX3- and PAX7-binding protein 1.	cyclin-L1; Belongs to the cyclin family.	0.631
LOC106156669	LOC106174844	A0A1S3HN87	A0A1S3JPE6	PAX3- and PAX7-binding protein 1.	Tuftelin-interacting protein 11 isoform X1.	0.899
LOC106156669	LOC106178645	A0A1S3HN87	A0A1S3K4B6	PAX3- and PAX7-binding protein 1.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.716
LOC106156669	LOC106179977	A0A1S3HN87	A0A1S3KAH2	PAX3- and PAX7-binding protein 1.	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1.	0.892
LOC106156669	LOC112042071	A0A1S3HN87	A0A2R2MP04	PAX3- and PAX7-binding protein 1.	pre-mRNA-processing factor 17-like.	0.670
LOC106168771	LOC106151197	A0A1S3IYW6	A0A1S3H179	U5 small nuclear ribonucleoprotein 200 kDa helicase.	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.942
LOC106168771	LOC106156669	A0A1S3IYW6	A0A1S3HN87	U5 small nuclear ribonucleoprotein 200 kDa helicase.	PAX3- and PAX7-binding protein 1.	0.588
LOC106168771	LOC106170224	A0A1S3IYW6	A0A1S3J5C2	U5 small nuclear ribonucleoprotein 200 kDa helicase.	pre-mRNA-splicing factor SYF2.	0.949
LOC106168771	LOC106170598	A0A1S3IYW6	A0A1S3J6F6	U5 small nuclear ribonucleoprotein 200 kDa helicase.	pre-mRNA-processing-splicing factor 8 isoform X2.	0.995
LOC106168771	LOC106174039	A0A1S3IYW6	A0A2R2MT95	U5 small nuclear ribonucleoprotein 200 kDa helicase.	pre-mRNA-processing factor 17.	0.893
LOC106168771	LOC106174844	A0A1S3IYW6	A0A1S3JPE6	U5 small nuclear ribonucleoprotein 200 kDa helicase.	Tuftelin-interacting protein 11 isoform X1.	0.666
LOC106168771	LOC106178645	A0A1S3IYW6	A0A1S3K4B6	U5 small nuclear ribonucleoprotein 200 kDa helicase.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.842

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Network Stats

number of nodes:

11

number of edges:

48

average node degree:

8.73

avg. local clustering coefficient:

0.933

expected number of edges:

11

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008299

Isoprenoid biosynthetic process

9 of 27

2.8

9.97

2.02e-20

GO:0016126

Sterol biosynthetic process

7 of 37

2.55

6.68

3.71e-14

GO:0046165

Alcohol biosynthetic process

8 of 87

2.24

6.02

3.00e-14

GO:1901617

Organic hydroxy compound biosynthetic process

9 of 132

2.11

5.91

3.32e-15

GO:0006695

Cholesterol biosynthetic process

6 of 27

2.62

5.84

3.98e-12

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004659

Prenyltransferase activity

4 of 15

2.7

3.57

2.14e-07

GO:0016765

Transferase activity, transferring alkyl or aryl (other than methyl) groups

5 of 49

2.29

3.46

1.16e-07

GO:0004337

Geranyltranstransferase activity

2 of 3

3.1

1.53

0.0017

GO:0004161

Dimethylallyltranstransferase activity

2 of 3

3.1

1.53

0.0017

GO:0016709

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

2 of 23

2.22

0.8

0.0333

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1904423

Dehydrodolichyl diphosphate synthase complex

2 of 2

3.28

1.51

0.0019

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5410

Isoprenoid biosynthetic process

8 of 15

3.0

9.98

1.04e-19

CL:5304

Steroid biosynthetic process, and Prenyltransferase activity

11 of 78

2.43

9.91

2.05e-23

CL:5413

Terpenoid backbone biosynthesis

7 of 8

3.22

9.37

4.27e-18

CL:5316

Steroid biosynthesis, and 3-beta hydroxysteroid dehydrogenase/isomerase family

3 of 21

2.43

2.07

0.00013

CL:5319

Steroid biosynthesis

2 of 8

2.68

1.32

0.0040

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

hcq00900

Terpenoid backbone biosynthesis

7 of 19

2.84

8.3

1.05e-16

hcq00100

Steroid biosynthesis

3 of 23

2.39

2.52

1.56e-05

hcq01100

Metabolic pathways

9 of 1363

1.1

1.38

9.08e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-191273

Cholesterol biosynthesis

8 of 31

2.69

8.39

1.89e-17

MAP-8957322

Metabolism of steroids

8 of 165

1.96

4.58

2.55e-12

MAP-446199

Synthesis of Dolichyl-phosphate

3 of 6

2.98

2.97

3.80e-06

MAP-556833

Metabolism of lipids

8 of 948

1.2

1.48

1.53e-06

MAP-446219

Synthesis of substrates in N-glycan biosythesis

3 of 86

1.82

1.23

0.0034

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1904423

Dehydrodolichyl diphosphate synthase complex

2 of 5

2.88

1.16

0.0080

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0756

Sterol biosynthesis

2 of 4

2.98

1.61

0.0012

KW-0752

Steroid biosynthesis

2 of 4

2.98

1.61

0.0012

KW-0808

Transferase

5 of 961

0.99

0.73

0.0051

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01255

Putative undecaprenyl diphosphate synthase

2 of 2

3.28

1.37

0.0034

PF00348

Polyprenyl synthetase

2 of 4

2.98

1.31

0.0043

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036424

Decaprenyl diphosphate synthase-like superfamily

2 of 2

3.28

1.1

0.0106

IPR033749

Polyprenyl synthetase, conserved site

2 of 3

3.1

1.1

0.0106

IPR000092

Polyprenyl synthetase

2 of 4

2.98

1.09

0.0106

IPR008949

Isoprenoid synthase domain superfamily

2 of 6

2.8

1.06

0.0123

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