LOC106161135 protein (Lingula anatina) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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gene co-occurrence

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Score

LOC106161135

Leucine-rich repeat-containing protein 69-like. (345 aa)

Predicted Functional Partners:

LOC106162206

0.584

LOC106165997

0.584

LOC106177882

0.584

LOC106161294

0.584

LOC106175432

0.518

LOC106164479

0.504

LOC106157383

0.495

LOC106169161

0.470

LOC106169163

0.465

LOC106152885

0.455

Your Current Organism:

Lingula anatina

NCBI taxonomy Id: 7574
Other names: L. anatina, Lingula lingua, Lingula unguis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106152885	LOC106161135	A0A1S3H7U3	A0A1S3I5F2	Slit homolog 2 protein.	Leucine-rich repeat-containing protein 69-like.	0.455
LOC106152885	LOC106161294	A0A1S3H7U3	A0A2R2MN25	Slit homolog 2 protein.	Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family.	0.579
LOC106152885	LOC106162206	A0A1S3H7U3	A0A1S3I9A0	Slit homolog 2 protein.	Uncharacterized protein LOC106162206; Belongs to the G-protein coupled receptor 2 family.	0.579
LOC106152885	LOC106165997	A0A1S3H7U3	A0A1S3INM4	Slit homolog 2 protein.	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	0.579
LOC106152885	LOC106177882	A0A1S3H7U3	A0A1S3K0T4	Slit homolog 2 protein.	Adhesion G protein-coupled receptor L3 isoform X2; Belongs to the G-protein coupled receptor 2 family.	0.579
LOC106157383	LOC106161135	A0A1S3HQY7	A0A1S3I5F2	Insulin-like growth factor-binding protein complex acid labile subunit.	Leucine-rich repeat-containing protein 69-like.	0.495
LOC106157383	LOC106161294	A0A1S3HQY7	A0A2R2MN25	Insulin-like growth factor-binding protein complex acid labile subunit.	Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family.	0.584
LOC106157383	LOC106162206	A0A1S3HQY7	A0A1S3I9A0	Insulin-like growth factor-binding protein complex acid labile subunit.	Uncharacterized protein LOC106162206; Belongs to the G-protein coupled receptor 2 family.	0.584
LOC106157383	LOC106165997	A0A1S3HQY7	A0A1S3INM4	Insulin-like growth factor-binding protein complex acid labile subunit.	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	0.584
LOC106157383	LOC106177882	A0A1S3HQY7	A0A1S3K0T4	Insulin-like growth factor-binding protein complex acid labile subunit.	Adhesion G protein-coupled receptor L3 isoform X2; Belongs to the G-protein coupled receptor 2 family.	0.584
LOC106161135	LOC106152885	A0A1S3I5F2	A0A1S3H7U3	Leucine-rich repeat-containing protein 69-like.	Slit homolog 2 protein.	0.455
LOC106161135	LOC106157383	A0A1S3I5F2	A0A1S3HQY7	Leucine-rich repeat-containing protein 69-like.	Insulin-like growth factor-binding protein complex acid labile subunit.	0.495
LOC106161135	LOC106161294	A0A1S3I5F2	A0A2R2MN25	Leucine-rich repeat-containing protein 69-like.	Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family.	0.584
LOC106161135	LOC106162206	A0A1S3I5F2	A0A1S3I9A0	Leucine-rich repeat-containing protein 69-like.	Uncharacterized protein LOC106162206; Belongs to the G-protein coupled receptor 2 family.	0.584
LOC106161135	LOC106164479	A0A1S3I5F2	A0A1S3IHZ9	Leucine-rich repeat-containing protein 69-like.	Leucine-rich repeats and immunoglobulin-like domains protein 3.	0.504
LOC106161135	LOC106165997	A0A1S3I5F2	A0A1S3INM4	Leucine-rich repeat-containing protein 69-like.	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	0.584
LOC106161135	LOC106169161	A0A1S3I5F2	A0A1S3J0L1	Leucine-rich repeat-containing protein 69-like.	Insulin-like growth factor-binding protein complex acid labile subunit.	0.470
LOC106161135	LOC106169163	A0A1S3I5F2	A0A1S3J0M3	Leucine-rich repeat-containing protein 69-like.	Protein artichoke.	0.465
LOC106161135	LOC106175432	A0A1S3I5F2	A0A1S3JRC1	Leucine-rich repeat-containing protein 69-like.	Slit homolog 1 protein.	0.518
LOC106161135	LOC106177882	A0A1S3I5F2	A0A1S3K0T4	Leucine-rich repeat-containing protein 69-like.	Adhesion G protein-coupled receptor L3 isoform X2; Belongs to the G-protein coupled receptor 2 family.	0.584

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Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.939

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006869

Lipid transport

6 of 12

2.48

5.02

1.05e-10

GO:0051701

Biological process involved in interaction with host

5 of 66

1.66

2.04

1.11e-05

GO:0070508

Cholesterol import

2 of 2

2.78

1.46

0.0022

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005548

Phospholipid transporter activity

4 of 4

2.78

3.56

2.44e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043190

ATP-binding cassette (ABC) transporter complex

4 of 49

1.69

1.68

0.00017

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8016

Mce/MlaD, and Permease MlaE

11 of 19

2.54

10.76

2.85e-24

CL:8017

Mce/MlaD, and Permease MlaE

8 of 10

2.68

8.39

1.84e-17

CL:8021

Mce/MlaD, and Sterol transport

5 of 5

2.78

5.12

2.21e-10

CL:8039

Phospholipid transport, and Sterol transport

3 of 5

2.56

2.4

3.38e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

11 of 318

1.32

2.34

5.42e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635465

Suppression of apoptosis

5 of 21

2.16

3.82

7.80e-09

MAP-9637690

Response of Mtb to phagocytosis

5 of 103

1.47

1.84

6.21e-06

MAP-9635486

Infection with Mycobacterium tuberculosis

5 of 258

1.07

0.98

0.00033

MAP-5663205

Infectious disease

5 of 259

1.07

0.98

0.00033

MAP-1643685

Disease

5 of 267

1.05

0.97

0.00033

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990351

Transporter complex

6 of 77

1.67

2.45

4.61e-07

GOCC:1990531

Phospholipid-translocating ATPase complex

2 of 2

2.78

1.69

0.00082

GOCC:0043190

ATP-binding cassette (ABC) transporter complex

4 of 63

1.58

1.44

0.00049

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02470

MlaD protein

5 of 12

2.4

3.91

1.98e-08

PF02405

Permease MlaE

4 of 4

2.78

3.75

1.07e-07

PF11887

Cholesterol uptake porter CUP1 of Mce4, putative

2 of 3

2.6

1.21

0.0062

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR024516

Mammalian cell entry, C-terminal

5 of 12

2.4

3.72

4.97e-08

IPR005693

Virulence factor Mce protein

5 of 12

2.4

3.72

4.97e-08

IPR003399

Mce/MlaD

5 of 12

2.4

3.72

4.97e-08

IPR030802

ABC transporter permease MalE

4 of 4

2.78

3.7

1.34e-07

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