LOC106178672 protein (Lingula anatina) - STRING interaction network

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Predicted Interactions

gene neighborhood

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gene co-occurrence

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Score

LOC106178672

Uncharacterized protein LOC106178672. (661 aa)

Predicted Functional Partners:

LOC106152283

0.496

LOC106166507

0.496

LOC106181165

0.496

LOC106169732

0.466

LOC106174693

0.466

LOC106154702

0.463

LOC106176078

0.463

LOC106158096

0.445

LOC106174490

0.445

LOC106165256

0.442

Your Current Organism:

Lingula anatina

NCBI taxonomy Id: 7574
Other names: L. anatina, Lingula lingua, Lingula unguis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106152283	LOC106154702	A0A1S3H5L3	A0A1S3HGK6	Uncharacterized protein LOC106152283.	78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family.	0.549
LOC106152283	LOC106158096	A0A1S3H5L3	A0A1S3HV43	Uncharacterized protein LOC106152283.	Caseinolytic peptidase B protein homolog isoform X1.	0.536
LOC106152283	LOC106165256	A0A1S3H5L3	A0A1S3ILA0	Uncharacterized protein LOC106152283.	Hypoxia up-regulated protein 1 isoform X1.	0.534
LOC106152283	LOC106166507	A0A1S3H5L3	A0A1S3ISM9	Uncharacterized protein LOC106152283.	Thioredoxin domain-containing protein 3 homolog isoform X1; Belongs to the NDK family.	0.656
LOC106152283	LOC106169732	A0A1S3H5L3	A0A1S3J2Z9	Uncharacterized protein LOC106152283.	grpE protein homolog 1, mitochondrial; Belongs to the GrpE family.	0.405
LOC106152283	LOC106174490	A0A1S3H5L3	A0A1S3JMZ3	Uncharacterized protein LOC106152283.	Caseinolytic peptidase B protein homolog.	0.536
LOC106152283	LOC106174693	A0A1S3H5L3	A0A1S3JN60	Uncharacterized protein LOC106152283.	grpE protein homolog 1, mitochondrial-like; Belongs to the GrpE family.	0.405
LOC106152283	LOC106176078	A0A1S3H5L3	A0A1S3JTV0	Uncharacterized protein LOC106152283.	Ankyrin repeat domain-containing protein 45.	0.549
LOC106152283	LOC106178672	A0A1S3H5L3	A0A1S3K452	Uncharacterized protein LOC106152283.	Uncharacterized protein LOC106178672.	0.496
LOC106152283	LOC106181165	A0A1S3H5L3	A0A1S3KE70	Uncharacterized protein LOC106152283.	Uncharacterized protein LOC106181165 isoform X1.	0.658
LOC106154702	LOC106152283	A0A1S3HGK6	A0A1S3H5L3	78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein LOC106152283.	0.549
LOC106154702	LOC106158096	A0A1S3HGK6	A0A1S3HV43	78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family.	Caseinolytic peptidase B protein homolog isoform X1.	0.663
LOC106154702	LOC106165256	A0A1S3HGK6	A0A1S3ILA0	78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family.	Hypoxia up-regulated protein 1 isoform X1.	0.997
LOC106154702	LOC106166507	A0A1S3HGK6	A0A1S3ISM9	78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family.	Thioredoxin domain-containing protein 3 homolog isoform X1; Belongs to the NDK family.	0.549
LOC106154702	LOC106169732	A0A1S3HGK6	A0A1S3J2Z9	78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family.	grpE protein homolog 1, mitochondrial; Belongs to the GrpE family.	0.697
LOC106154702	LOC106174490	A0A1S3HGK6	A0A1S3JMZ3	78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family.	Caseinolytic peptidase B protein homolog.	0.663
LOC106154702	LOC106174693	A0A1S3HGK6	A0A1S3JN60	78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family.	grpE protein homolog 1, mitochondrial-like; Belongs to the GrpE family.	0.697
LOC106154702	LOC106178672	A0A1S3HGK6	A0A1S3K452	78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein LOC106178672.	0.463
LOC106154702	LOC106181165	A0A1S3HGK6	A0A1S3KE70	78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein LOC106181165 isoform X1.	0.549
LOC106158096	LOC106152283	A0A1S3HV43	A0A1S3H5L3	Caseinolytic peptidase B protein homolog isoform X1.	Uncharacterized protein LOC106152283.	0.536

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.776

expected number of edges:

13

PPI enrichment p-value:

0.000137

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006596

Polyamine biosynthetic process

6 of 25

3.01

6.95

1.07e-13

GO:0006591

Ornithine metabolic process

5 of 14

3.18

6.26

3.26e-12

GO:0006525

Arginine metabolic process

5 of 20

3.02

5.9

1.19e-11

GO:1901605

Alpha-amino acid metabolic process

9 of 321

2.07

5.54

1.97e-14

GO:0009446

Putrescine biosynthetic process

4 of 8

3.32

5.14

4.61e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016813

Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

5 of 16

3.12

5.87

1.61e-11

GO:0004053

Arginase activity

3 of 3

3.63

3.62

3.05e-07

GO:0008783

Agmatinase activity

2 of 2

3.63

2.01

0.00024

GO:0017061

S-methyl-5-thioadenosine phosphorylase activity

2 of 4

3.32

1.89

0.00039

GO:0004586

Ornithine decarboxylase activity

2 of 5

3.23

1.88

0.00041

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:3761021

(1986) Urea cycle activity and arginine formation in rainbow trout (Salmo gairdneri)

3 of 3

3.63

3.43

6.78e-07

PMID:29238889

(2018) Immunomodulatory effects of Rhodomyrtus tomentosa leaf extract and its derivative compound, rhodomyrtone, on head kidney macrophages of rainbow trout (Oncorhynchus mykiss).

3 of 3

3.63

3.43

6.78e-07

PMID:26600157

(2015) Widespread Natural Occurrence of Hydroxyurea in Animals.

3 of 3

3.63

3.43

6.78e-07

PMID:34578212

(2021) Intestinal Transcriptomic and Histologic Profiling Reveals Tissue Repair Mechanisms Underlying Resistance to the Parasite Ceratonova shasta.

3 of 5

3.4

3.42

6.78e-07

PMID:34201988

(2021) Post-Prandial Amino Acid Changes in Gilthead Sea Bream.

3 of 5

3.4

3.42

6.78e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:55228

Arginase, and Agmatinase activity

5 of 5

3.63

6.76

5.91e-13

CL:57371

Polyamine biosynthetic process, and UDP-N-acetylglucosamine biosynthetic process

3 of 34

2.57

2.19

8.74e-05

CL:60604

Mixed, incl. S-methyl-5-thioadenosine phosphorylase activity, and Spermine synthase, animal

2 of 6

3.15

1.57

0.0015

CL:57417

Ornithine decarboxylase, and Ornithine decarboxylase antizyme

2 of 6

3.15

1.57

0.0015

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00330

Arginine and proline metabolism

9 of 199

2.28

7.41

6.59e-18

map00270

Cysteine and methionine metabolism

4 of 157

2.03

2.64

2.98e-06

map00220

Arginine biosynthesis

3 of 73

2.24

2.3

3.42e-05

map00480

Glutathione metabolism

3 of 194

1.81

1.59

0.00048

map01230

Biosynthesis of amino acids

3 of 278

1.66

1.35

0.0012

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-351143

Agmatine biosynthesis

4 of 4

3.63

5.54

1.00e-10

MAP-71291

Metabolism of amino acids and derivatives

11 of 664

1.84

5.28

9.44e-18

MAP-351202

Metabolism of polyamines

6 of 153

2.22

4.43

3.73e-10

MAP-70635

Urea cycle

3 of 11

3.06

3.25

1.21e-06

MAP-1237112

Methionine salvage pathway

2 of 6

3.15

1.88

0.00040

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0835

Urea cycle

3 of 3

3.63

3.98

6.89e-08

KW-0056

Arginine metabolism

3 of 3

3.63

3.98

6.89e-08

KW-0620

Polyamine biosynthesis

2 of 4

3.32

2.25

8.65e-05

KW-0464

Manganese

3 of 75

2.23

2.1

8.65e-05

KW-0378

Hydrolase

4 of 950

1.25

0.94

0.0036

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00491

Arginase family

4 of 4

3.63

5.2

4.09e-10

PF02784

Pyridoxal-dependent decarboxylase, pyridoxal binding domain

2 of 5

3.23

1.52

0.0018

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020855

Ureohydrolase, manganese-binding site

4 of 4

3.63

4.95

1.19e-09

IPR006035

Ureohydrolase

4 of 4

3.63

4.95

1.19e-09

IPR023696

Ureohydrolase domain superfamily

4 of 30

2.75

3.54

2.61e-07

IPR014033

Arginase

3 of 3

3.63

3.5

4.92e-07

IPR022657

Orn/DAP/Arg decarboxylase 2, conserved site

2 of 3

3.45

1.67

0.0010

(more ...)

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