node1 | node2 | node1 annotation | node2 annotation | score |
A0A0K0EZQ1 | A0A0K0F4B7 | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | 2O16 (inferred by orthology to a C. elegans protein). | 0.900 |
A0A0K0EZQ1 | A0A0K0F718 | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | Cysteine desulfurase, mitochondrial (inferred by orthology to a human protein). | 0.945 |
A0A0K0EZQ1 | A0A0K0F7E2 | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | MoCF_biosynth domain-containing protein. | 0.751 |
A0A0K0EZQ1 | A0A0K0F867 | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (inferred by orthology to a human protein); Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | 0.540 |
A0A0K0EZQ1 | A0A0K0FQZ8 | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | Molybdenum cofactor sulfurase (inferred by orthology to a C. elegans protein). | 0.876 |
A0A0K0EZQ1 | A0A0K0FVC6 | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. | 0.751 |
A0A0K0EZQ1 | A0A0K0FYQ7 | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | Iron-sulfur cluster assembly 1 homolog, mitochondrial (inferred by orthology to a human protein). | 0.645 |
A0A0K0EZQ1 | A0A0K0FZ19 | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | Probable selenide, water dikinase (inferred by orthology to a C. elegans protein). | 0.548 |
A0A0K0F4B7 | A0A0K0EZQ1 | 2O16 (inferred by orthology to a C. elegans protein). | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | 0.900 |
A0A0K0F4B7 | A0A0K0F867 | 2O16 (inferred by orthology to a C. elegans protein). | Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (inferred by orthology to a human protein); Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | 0.998 |
A0A0K0F4B7 | A0A0K0F8U3 | 2O16 (inferred by orthology to a C. elegans protein). | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.464 |
A0A0K0F4B7 | A0A0K0FQZ8 | 2O16 (inferred by orthology to a C. elegans protein). | Molybdenum cofactor sulfurase (inferred by orthology to a C. elegans protein). | 0.910 |
A0A0K0F4B7 | A0A0K0FWH2 | 2O16 (inferred by orthology to a C. elegans protein). | Nfu_N domain-containing protein. | 0.975 |
A0A0K0F4B7 | A0A0K0FYQ7 | 2O16 (inferred by orthology to a C. elegans protein). | Iron-sulfur cluster assembly 1 homolog, mitochondrial (inferred by orthology to a human protein). | 0.917 |
A0A0K0F4B7 | A0A0K0FZ19 | 2O16 (inferred by orthology to a C. elegans protein). | Probable selenide, water dikinase (inferred by orthology to a C. elegans protein). | 0.851 |
A0A0K0F718 | A0A0K0EZQ1 | Cysteine desulfurase, mitochondrial (inferred by orthology to a human protein). | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | 0.945 |
A0A0K0F718 | A0A0K0F867 | Cysteine desulfurase, mitochondrial (inferred by orthology to a human protein). | Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (inferred by orthology to a human protein); Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | 0.999 |
A0A0K0F718 | A0A0K0F8U3 | Cysteine desulfurase, mitochondrial (inferred by orthology to a human protein). | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.464 |
A0A0K0F718 | A0A0K0FQZ8 | Cysteine desulfurase, mitochondrial (inferred by orthology to a human protein). | Molybdenum cofactor sulfurase (inferred by orthology to a C. elegans protein). | 0.910 |
A0A0K0F718 | A0A0K0FWH2 | Cysteine desulfurase, mitochondrial (inferred by orthology to a human protein). | Nfu_N domain-containing protein. | 0.982 |