Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AKA10259.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)    
Predicted Functional Partners:
AKA10411.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.772
AKA12359.1
Autotransporter adhesin; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.759
tbp1_4
Transferrin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.749
AKA11850.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.742
AKA10449.1
Patatin; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.719
AKA12554.1
Surface antigen; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.709
lktC
Leukotoxin-activating lysine-acyltransferase LktC; Involved in fatty acylation of the protoxin (LktA) at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP (By similarity); Belongs to the RTX toxin acyltransferase family.
  
     0.705
hxuC_1
FetA; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.692
lapB
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.691
lktA
Hemolysin; Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture. The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca(2+) and lysis of the host cell. This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis. It has also week hemolytic activity.
  
     0.663
Your Current Organism:
Mannheimia haemolytica
NCBI taxonomy Id: 75985
Other names: ATCC 33396, CCUG 12392, CCUG 408, CIP 103426, DSM 10531, M. haemolytica, NCTC 9380, Pasteurella haemolytica, strain J.A. Watt 1266AB
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