Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cvaA_2Secretion permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)    
Predicted Functional Partners:
lktB
Peptidase C39; Part of the ABC transporter complex LktBD involved in leukotoxin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable).
 
 0.956
macB_3
Macrolide transporter; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
  
 0.801
AKA10997.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.773
cusC
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.708
lktA
Hemolysin; Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture. The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca(2+) and lysis of the host cell. This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis. It has also week hemolytic activity.
 
  
 0.501
lktC
Leukotoxin-activating lysine-acyltransferase LktC; Involved in fatty acylation of the protoxin (LktA) at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP (By similarity); Belongs to the RTX toxin acyltransferase family.
 
   
 0.458
AKA10996.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
       0.408
Your Current Organism:
Mannheimia haemolytica
NCBI taxonomy Id: 75985
Other names: ATCC 33396, CCUG 12392, CCUG 408, CIP 103426, DSM 10531, M. haemolytica, NCTC 9380, Pasteurella haemolytica, strain J.A. Watt 1266AB
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