Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tolRColicin uptake protein TolR; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (145 aa)    
Predicted Functional Partners:
tolQ
Colicin uptake protein TolQ; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
 
 
 0.992
tolB_2
Translocation protein TolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
  
 0.986
exbB
Energy transducer TonB; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity).
 
 
 0.929
AKA11026.1
Peptidoglycan-associated outer membrane lipoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.922
tonB
Energy transducer TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity); Belongs to the TonB family.
  
 
 0.913
AKA11024.1
Cell envelope biogenesis protein TolA; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.863
yaeT_2
Part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.699
exbD
Biopolymer transporter ExbD; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
  
   
 0.675
lolC
Permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.673
ybgC
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.621
Your Current Organism:
Mannheimia haemolytica
NCBI taxonomy Id: 75985
Other names: ATCC 33396, CCUG 12392, CCUG 408, CIP 103426, DSM 10531, M. haemolytica, NCTC 9380, Pasteurella haemolytica, strain J.A. Watt 1266AB
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