Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mazG_1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (97 aa)    
Predicted Functional Partners:
AKA11414.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     0.994
nadR_1
Transcriptional regulator; Catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; catalyzes the formation of nicotinamide mononucleotide from nicotinamide riboside; also has a regulatory function; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.811
mazG_2
Nucleoside triphosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.773
yycF
Response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.615
ribBA_2
GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the N-terminal section; belongs to the DHBP synthase family.
    
  0.510
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
    
  0.486
pyrR
Uracil phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
  0.459
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
   
 
 0.445
pyrG
CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.413
adk_1
Adenylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.413
Your Current Organism:
Mannheimia haemolytica
NCBI taxonomy Id: 75985
Other names: ATCC 33396, CCUG 12392, CCUG 408, CIP 103426, DSM 10531, M. haemolytica, NCTC 9380, Pasteurella haemolytica, strain J.A. Watt 1266AB
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