gdhA_1 protein (Mannheimia haemolytica) - STRING interaction network

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Mannheimia haemolytica

NCBI taxonomy Id: 75985
Other names: ATCC 33396, CCUG 12392, CCUG 408, CIP 103426, DSM 10531, M. haemolytica, NCTC 9380, Pasteurella haemolytica, strain J.A. Watt 1266AB

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
argA	aspC	WC39_07165	WC39_06930	N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetyltransferase family. ArgA subfamily.	Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.983
argA	gdhA_1	WC39_07165	WC39_07425	N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetyltransferase family. ArgA subfamily.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.982
argA	glnA	WC39_07165	WC39_01275	N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetyltransferase family. ArgA subfamily.	Forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.538
argA	gltA	WC39_07165	WC39_07005	N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetyltransferase family. ArgA subfamily.	Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.	0.452
argA	putA	WC39_07165	WC39_12365	N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetyltransferase family. ArgA subfamily.	Proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	0.440
aspC	argA	WC39_06930	WC39_07165	Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetyltransferase family. ArgA subfamily.	0.983
aspC	gdhA_1	WC39_06930	WC39_07425	Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.987
aspC	gltA	WC39_06930	WC39_07005	Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.	0.987
aspC	gshAB_5	WC39_06930	WC39_02100	Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Bifunctional glutamate--cysteine ligase/glutathione synthetase; Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine; In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.	0.976
aspC	icd_1	WC39_06930	WC39_07010	Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.984
aspC	mdh_2	WC39_06930	WC39_03015	Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.	0.989
aspC	putA	WC39_06930	WC39_12365	Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	0.979
aspC	sucA_2	WC39_06930	WC39_06065	Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoglutarate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.978
gdhA_1	argA	WC39_07425	WC39_07165	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetyltransferase family. ArgA subfamily.	0.982
gdhA_1	aspC	WC39_07425	WC39_06930	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.987
gdhA_1	glnA	WC39_07425	WC39_01275	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.986
gdhA_1	gltA	WC39_07425	WC39_07005	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.	0.986
gdhA_1	gshAB_5	WC39_07425	WC39_02100	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Bifunctional glutamate--cysteine ligase/glutathione synthetase; Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine; In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.	0.985
gdhA_1	icd_1	WC39_07425	WC39_07010	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.991
gdhA_1	lpdA_2	WC39_07425	WC39_07835	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981

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