Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
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[Homology]
Score
mepAD-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)    
Predicted Functional Partners:
yfcA_2
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    0.792
AKA10651.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.756
aroC_2
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
    0.753
menE_3
O-succinylbenzoic acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.741
seqA_1
Negative modulator of initiation of replication; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.732
AKA11704.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.721
ycjX_2
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.610
ampD
N-acetyl-anhydromuranmyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.568
topB_2
DNA topoisomerase III; Decatenates replicating daughter chromosomes; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.566
AKA12696.1
L,D-transpeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.564
Your Current Organism:
Mannheimia haemolytica
NCBI taxonomy Id: 75985
Other names: ATCC 33396, CCUG 12392, CCUG 408, CIP 103426, DSM 10531, M. haemolytica, NCTC 9380, Pasteurella haemolytica, strain J.A. Watt 1266AB
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