Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AKA11710.1Bacteriophage protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (622 aa)    
Predicted Functional Partners:
AKA11711.1
Tail protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.768
polA_3
DNA polymerase I; Has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.650
AKA11122.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.635
AKA12486.1
Serine recombinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.485
AKA12119.1
Phage tail protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
   0.475
lktA
Hemolysin; Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture. The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca(2+) and lysis of the host cell. This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis. It has also week hemolytic activity.
   
   0.474
fsr_3
MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.418
fsr_2
Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.418
fsr_1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.418
AKA11112.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
   0.405
Your Current Organism:
Mannheimia haemolytica
NCBI taxonomy Id: 75985
Other names: ATCC 33396, CCUG 12392, CCUG 408, CIP 103426, DSM 10531, M. haemolytica, NCTC 9380, Pasteurella haemolytica, strain J.A. Watt 1266AB
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