| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| fadD_3 | rseA | WC39_09455 | WC39_09470 | Long-chain fatty acid--CoA ligase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. | sigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic p [...] | 0.471 |
| fadD_3 | rseB_1 | WC39_09455 | WC39_09465 | Long-chain fatty acid--CoA ligase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sigma E regulator RseB; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.773 |
| fadD_3 | rseC | WC39_09455 | WC39_09460 | Long-chain fatty acid--CoA ligase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. | sigma-E factor regulatory protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.773 |
| fadD_3 | upp | WC39_09455 | WC39_09450 | Long-chain fatty acid--CoA ligase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.701 |
| hflD | rseC | WC39_05135 | WC39_09460 | Lysogenization regulator; HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; Derived by automated computational analysis using gene prediction method: Protein Homology. | sigma-E factor regulatory protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.403 |
| rnfC_2 | rnfD | WC39_10350 | WC39_10340 | Electron transporter RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. | Electron transporter RnfD; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the NqrB/RnfD family. | 0.998 |
| rnfC_2 | rseC | WC39_10350 | WC39_09460 | Electron transporter RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. | sigma-E factor regulatory protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.561 |
| rnfC_2 | rsxG | WC39_10350 | WC39_10335 | Electron transporter RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. | Electron transporter RnfG; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family. | 0.997 |
| rnfD | rnfC_2 | WC39_10340 | WC39_10350 | Electron transporter RnfD; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the NqrB/RnfD family. | Electron transporter RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. | 0.998 |
| rnfD | rseC | WC39_10340 | WC39_09460 | Electron transporter RnfD; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the NqrB/RnfD family. | sigma-E factor regulatory protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.444 |
| rnfD | rsxG | WC39_10340 | WC39_10335 | Electron transporter RnfD; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the NqrB/RnfD family. | Electron transporter RnfG; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family. | 0.999 |
| rpoE | rseA | WC39_09475 | WC39_09470 | RNA polymerase sigma factor RpoE; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. | sigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic p [...] | 0.987 |
| rpoE | rseB_1 | WC39_09475 | WC39_09465 | RNA polymerase sigma factor RpoE; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. | Sigma E regulator RseB; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.859 |
| rpoE | rseC | WC39_09475 | WC39_09460 | RNA polymerase sigma factor RpoE; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. | sigma-E factor regulatory protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.551 |
| rseA | fadD_3 | WC39_09470 | WC39_09455 | sigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic p [...] | Long-chain fatty acid--CoA ligase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.471 |
| rseA | rpoE | WC39_09470 | WC39_09475 | sigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic p [...] | RNA polymerase sigma factor RpoE; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. | 0.987 |
| rseA | rseB_1 | WC39_09470 | WC39_09465 | sigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic p [...] | Sigma E regulator RseB; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.996 |
| rseA | rseC | WC39_09470 | WC39_09460 | sigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic p [...] | sigma-E factor regulatory protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.814 |
| rseA | upp | WC39_09470 | WC39_09450 | sigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic p [...] | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.433 |
| rseB_1 | fadD_3 | WC39_09465 | WC39_09455 | Sigma E regulator RseB; Derived by automated computational analysis using gene prediction method: Protein Homology. | Long-chain fatty acid--CoA ligase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.773 |