Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ssa1Peptidase S8; Derived by automated computational analysis using gene prediction method: Protein Homology. (934 aa)    
Predicted Functional Partners:
lktA
Hemolysin; Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture. The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca(2+) and lysis of the host cell. This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis. It has also week hemolytic activity.
  
 
 0.682
AKA10335.1
Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.599
AKA12727.1
Peptide transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.579
AKA10660.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.530
AKA11224.1
Peptide ABC transporter ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.530
AKA11055.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.525
ssa1_1
Peptidase S8; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
0.523
AKA11892.1
ATP-dependent helicase HrpA; Involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.450
AKA12734.1
Type VI secretion protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.411
Your Current Organism:
Mannheimia haemolytica
NCBI taxonomy Id: 75985
Other names: ATCC 33396, CCUG 12392, CCUG 408, CIP 103426, DSM 10531, M. haemolytica, NCTC 9380, Pasteurella haemolytica, strain J.A. Watt 1266AB
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