Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nudBDihydroneopterin triphosphate pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)    
Predicted Functional Partners:
folE
GTP cyclohydrolase; Involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
  0.988
queD
6-carboxy-5,6,7,8-tetrahydropterin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.976
AKA12166.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.860
AKA11263.1
Nucleoside-triphosphate diphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.650
AKA12172.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.637
holD
DNA polymerase III subunit psi; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown.
  
   
 0.618
aspS_4
aspartyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
  
   0.598
ribBA_2
GTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the N-terminal section; belongs to the DHBP synthase family.
   
 0.563
lptD_3
LPS biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.559
mukF
Condesin subunit F; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.
  
     0.529
Your Current Organism:
Mannheimia haemolytica
NCBI taxonomy Id: 75985
Other names: ATCC 33396, CCUG 12392, CCUG 408, CIP 103426, DSM 10531, M. haemolytica, NCTC 9380, Pasteurella haemolytica, strain J.A. Watt 1266AB
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