STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (300 aa)    
Predicted Functional Partners:
exoA
Exodeoxyribonuclease-3.
    
 0.943
cshB
ATP-dependent RNA helicase CshB; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures.
 
    0.888
nth
DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.851
recJ
single-stranded-DNA-specific exonuclease.
  
  
 0.688
SKA88330.1
YqfQ-like protein.
       0.594
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 
 0.541
ung
Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
   
 
 0.502
ispH
4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
       0.483
SKA91290.1
DNA polymerase (family 10).
   
  
 0.478
ppaC
Manganese-dependent inorganic pyrophosphatase.
  
    0.451
Your Current Organism:
Sporosarcina newyorkensis
NCBI taxonomy Id: 759851
Other names: CCUG 59649, DSM 23544, LMG 26022, LMG:26022, S. newyorkensis, Sporosarcina newyorkensis Wolfgang et al. 2012, Sporosarcina sp. 3418, Sporosarcina sp. 4331, Sporosarcina sp. 4469, Sporosarcina sp. 4974, Sporosarcina sp. 4984, Sporosarcina sp. 5353, Sporosarcina sp. 57, Sporosarcina sp. 5868, Sporosarcina sp. 6062, Sporosarcina sp. R-31323, strain 6062
Server load: low (6%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.