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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEC02861.1Transcriptional regulator, LacI family; COGs: COG1609 Transcriptional regulators; InterPro IPR000843:IPR001761; KEGG: smd:Smed_4315 periplasmic binding protein/LacI transcriptional regulator; PFAM: Periplasmic binding protein/LacI transcriptional regulator; HTH transcriptional regulator, LacI; SMART: HTH transcriptional regulator, LacI; SPTR: Periplasmic binding protein/LacI transcriptional regulator; IMG reference gene:2503957977; PFAM: Bacterial regulatory proteins, lacI family; family. (374 aa)    
Predicted Functional Partners:
AEC02469.1
Transcriptional regulator, LacI family; COGs: COG1609 Transcriptional regulators; InterPro IPR000843:IPR001761; KEGG: dap:Dacet_0215 transcriptional regulator, LacI family; PFAM: HTH transcriptional regulator, LacI; Periplasmic binding protein/LacI transcriptional regulator; SMART: HTH transcriptional regulator, LacI; SPTR: Transcriptional regulator, LacI family; IMG reference gene:2503957569; PFAM: Bacterial regulatory proteins, lacI family; family.
  
     0.774
AEC01297.1
Transcriptional regulator, AraC family; COGs: COG1609 Transcriptional regulators; InterPro IPR001761:IPR000005:IPR018060; KEGG: cag:Cagg_2054 two component transcriptional regulator, AraC family; PFAM: HTH transcriptional regulator, AraC; Periplasmic binding protein/LacI transcriptional regulator; SMART: Helix-turn-helix, AraC type, DNA binding domain; SPTR: Two component transcriptional regulator, AraC family; IMG reference gene:2503956319; PFAM: Bacterial regulatory helix-turn-helix proteins, AraC family; family.
  
  
 0.683
AEC02862.1
RbsD or FucU transport; COGs: COG4154 Fucose dissimilation pathway protein FucU; InterPro IPR007721; KEGG: pjd:Pjdr2_1349 RbsD or FucU transport; PFAM: D-ribose pyranase RbsD/L-fucose mutarotase FucU; SPTR: Fucose operon protein FucU; IMG reference gene:2503957978; PFAM: RbsD / FucU transport protein family; Belongs to the RbsD / FucU family.
       0.650
AEC01801.1
Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: pdi:BDI_0326 glutamate synthase, large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase, large subunit; IMG reference gene:2503956852; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
    
 
 0.584
AEC01952.1
Histidine kinase; COGs: COG1609 Transcriptional regulators; InterPro IPR001761:IPR003594; KEGG: ssm:Spirs_1217 ATP-binding region ATPase domain protein; PFAM: ATPase-like, ATP-binding domain; Periplasmic binding protein/LacI transcriptional regulator; SMART: ATPase-like, ATP-binding domain; SPTR: Histidine kinase; IMG reference gene:2503957016; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; family.
  
     0.563
AEC01579.1
COGs: COG0469 Pyruvate kinase; InterPro IPR015793:IPR015795:IPR001697; KEGG: cob:COB47_1291 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, C-terminal-like; PRIAM: Pyruvate kinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; IMG reference gene:2503956622; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
    
 
 0.480
fucI
L-fucose isomerase; Converts the aldose L-fucose into the corresponding ketose L- fuculose.
       0.454
AEC02712.1
COGs: COG1925 Phosphotransferase system HPr-related protein; InterPro IPR005698; KEGG: eel:EUBELI_20516 phosphocarrier protein HPr; PFAM: Phosphotransferase system, phosphocarrier HPr protein; SPTR: Putative uncharacterized protein; TIGRFAM: Phosphotransferase system, phosphocarrier HPr protein; IMG reference gene:2503957823; PFAM: PTS HPr component phosphorylation site; TIGRFAM: Phosphotransferase System HPr (HPr) Family.
   
 
 0.434
AEC02791.1
COGs: COG1925 Phosphotransferase system HPr-related protein; InterPro IPR005698; KEGG: ssm:Spirs_4051 phosphotransferase system, phosphocarrier protein HPr; PFAM: Phosphotransferase system, phosphocarrier HPr protein; SPTR: Phosphocarrier protein HPr; TIGRFAM: Phosphotransferase system, phosphocarrier HPr protein; IMG reference gene:2503957903; PFAM: PTS HPr component phosphorylation site; TIGRFAM: Phosphotransferase System HPr (HPr) Family.
   
 
 0.434
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
    
   0.426
Your Current Organism:
Sphaerochaeta coccoides
NCBI taxonomy Id: 760011
Other names: S. coccoides DSM 17374, Sphaerochaeta coccoides DSM 17374, Sphaerochaeta coccoides str. DSM 17374, Sphaerochaeta coccoides strain DSM 17374, Spirochaeta coccoides DSM 17374, Spirochaeta coccoides SPN1, Spirochaeta sp. SPN1
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