Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
luxSLuxS protein involved in autoinducer AI2 synthesis; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (168 aa)    
Predicted Functional Partners:
AFL67891.1
Adenosylhomocysteine nucleosidase,methylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
 
 
 0.983
AFL68826.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.954
metE
Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
    
 0.938
AFL68302.1
Homocysteine/selenocysteine methylase (S-methylmethionine-dependent); PFAM: Homocysteine S-methyltransferase.
     
 0.910
AFL68795.1
Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; PFAM: Aminotransferase class I and II.
     
 0.903
AFL68680.1
O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase.
     
 0.901
AFL69223.1
O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase.
     
 0.901
AFL69663.1
O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme.
     
 0.901
AFL68682.1
Cysteine synthase A; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 
 0.898
AFL67514.1
PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain.
     
 0.812
Your Current Organism:
Sulfurospirillum barnesii
NCBI taxonomy Id: 760154
Other names: S. barnesii SES-3, Sulfurospirillum barnesii SES-3, Sulfurospirillum barnesii str. SES-3, Sulfurospirillum barnesii strain SES-3
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