Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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AEE48021.1ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterPro IPR003593:IPR013093:IPR019489; KEGG: hch:HCH_05499 chaperone activity ATPase ATP-binding subunit; PFAM: ATPase associated with various cellular activities, AAA-2; Clp ATPase, C-terminal; SPTR: Chaperone ClpB, putative; IMG reference gene:2504769458; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein. (755 aa)    
Predicted Functional Partners:
clpP-2
ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
 
 
 0.754
clpP
ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
 
 
 0.738
AEE48022.1
Protein of unknown function DUF819; COGs: COG5505 integral membrane protein; InterPro IPR008537; KEGG: ssm:Spirs_3917 protein of unknown function DUF819; PFAM: Protein of unknown function DUF819; SPTR: Conserved uncharacterized protein; IMG reference gene:2504769459; PFAM: Protein of unknown function (DUF819).
       0.718
grpE
Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.697
AEE53655.1
Heat shock protein 70; COGs: COG0443 Molecular chaperone; InterPro IPR013126; KEGG: phe:Phep_3231 Fe-S protein assembly chaperone HscA; PFAM: Heat shock protein 70; SPTR: Heat shock protein 70; IMG reference gene:2504775230; PFAM: Hsp70 protein; TIGRFAM: Fe-S protein assembly chaperone HscA.
 
 
 0.695
dnaK
Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 
 0.692
AEE51842.1
InterPro IPR003769; KEGG: gfo:GFO_0434 ATP-dependent Clp protease adaptor protein; PFAM: Adaptor protein ClpS, core; SPTR: ATP-dependent Clp protease adaptor protein ClpS; IMG reference gene:2504773379; PFAM: ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family.
  
 
 0.660
AEE52920.1
Heat shock protein 70; COGs: COG0443 Molecular chaperone; InterPro IPR013126; KEGG: sli:Slin_5724 TIR protein; PFAM: Heat shock protein 70; SPTR: TIR protein; IMG reference gene:2504774492; PFAM: Hsp70 protein.
  
 
 0.650
AEE52926.1
Heat shock protein; COGs: COG0443 Molecular chaperone; KEGG: chu:CHU_2145 heat shock protein; SPTR: Probable heat shock protein; IMG reference gene:2504774498; PFAM: Hsp70 protein.
  
 
 0.650
AEE50442.1
InterPro IPR003594; KEGG: mpi:Mpet_2164 ATP-binding region ATPase domain-containing protein; PFAM: ATP-binding region, ATPase-like; SPTR: Putative uncharacterized protein; IMG reference gene:2504771942; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
  
 
 0.555
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
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