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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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AEE48100.1Heat shock protein Hsp20; COGs: COG0071 Molecular chaperone (small heat shock protein); InterPro IPR002068; KEGG: cpi:Cpin_6319 heat shock protein HSP20; PFAM: Heat shock protein Hsp20; SPTR: Heat shock protein Hsp20; IMG reference gene:2504769539; PFAM: Hsp20/alpha crystallin family; Belongs to the small heat shock protein (HSP20) family. (150 aa)    
Predicted Functional Partners:
AEE51216.1
ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR003593:IPR004176:IPR003959:IPR013093:IPR 019489; KEGG: phe:Phep_1456 ATP-dependent chaperone ClpB; PFAM: ATPase associated with various cellular activities, AAA-2; ATPase, AAA-type, core; Clp, N-terminal; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATP-dependent chaperone ClpB; IMG reference gene:2504772738; PFAM: AAA domain (Cdc48 subfamily); Clp amino terminal domain; C-terminal, D2-small domain, of ClpB protein; ATPase family associated with various cellular ac [...]
 
 
 0.584
nnrD
YjeF-related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...]
 
  
 0.539
AEE48099.1
Protease Do; COGs: COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain; InterPro IPR001478:IPR001254:IPR011782; KEGG: rbi:RB2501_06610 serine protease; PFAM: Peptidase S1/S6, chymotrypsin/Hap; PDZ/DHR/GLGF; PRIAM: HtrA2 peptidase; SMART: PDZ/DHR/GLGF; SPTR: Serine protease; TIGRFAM: Peptidase S1C, Do; IMG reference gene:2504769538; PFAM: Trypsin; PDZ domain (Also known as DHR or GLGF); TIGRFAM: periplasmic serine protease, Do/DeqQ family.
   
 
 0.533
AEE48021.1
ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterPro IPR003593:IPR013093:IPR019489; KEGG: hch:HCH_05499 chaperone activity ATPase ATP-binding subunit; PFAM: ATPase associated with various cellular activities, AAA-2; Clp ATPase, C-terminal; SPTR: Chaperone ClpB, putative; IMG reference gene:2504769458; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein.
  
 
 0.507
AEE53002.1
ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176:IPR003959:IPR001943:IPR013093:IPR 019489:IPR003593; KEGG: cpi:Cpin_6630 ATPase AAA-2 domain protein; PFAM: ATPase associated with various cellular activities, AAA-2; Clp, N-terminal; ATPase, AAA-type, core; UvrB/UvrC protein; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATPase AAA-2 domain protein; IMG reference gene:2504774574; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associat [...]
  
 
 0.507
AEE54171.1
ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterPro IPR013093:IPR019489:IPR003593; KEGG: hch:HCH_05498 chaperone activity ATPase ATP-binding subunit; PFAM: ATPase associated with various cellular activities, AAA-2; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATPases with chaperone activity ClpC, two ATP-binding domain; IMG reference gene:2504775760; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein.
  
 
 0.507
AEE54236.1
ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterPro IPR003593:IPR013093:IPR019489; KEGG: hch:HCH_05497 chaperone activity ATPase ATP-binding subunit; PFAM: ATPase associated with various cellular activities, AAA-2; Clp ATPase, C-terminal; SPTR: ATP-dependent Clp protease, ATP-binding subunit ClpC, putative; IMG reference gene:2504775826; PFAM: AAA domain (Cdc48 subfamily); Archaeal ATPase; C-terminal, D2-small domain, of ClpB protein.
  
 
 0.507
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
  
 0.463
grpE
Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.413
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
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