STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEE48152.1Cytidyltransferase-related domain protein; COGs: COG3172 ATPase/kinase involved in NAD metabolism; KEGG: gym:GYMC10_6274 cytidyltransferase-related domain protein; SPTR: Cytidyltransferase-related domain protein; IMG reference gene:2504769591; TIGRFAM: nicotinamide-nucleotide adenylyltransferase, NadR type; cytidyltransferase-related domain. (337 aa)    
Predicted Functional Partners:
cobB
COGs: COG0846 NAD-dependent protein deacetylase SIR2 family; HAMAP: NAD-dependent deacetylase; InterPro IPR003000; KEGG: zpr:ZPR_2106 NAD-dependent histone deacetylase; PFAM: NAD-dependent histone deacetylase, silent information regulator Sir2; SPTR: Putative uncharacterized protein; IMG reference gene:2504775815; PFAM: Sir2 family; Belongs to the sirtuin family. Class III subfamily.
   
 
 0.992
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.952
AEE48004.1
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
    
 0.937
nadK
Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.937
AEE51433.1
Competence/damage-inducible protein CinA; COGs: COG1058 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; InterPro IPR008135:IPR008136:IPR001453; KEGG: sli:Slin_1357 competence/damage-inducible protein CinA; PFAM: CinA, C-terminal; Molybdopterin binding; SPTR: CinA-like protein; TIGRFAM: Competence-induced protein CinA; CinA, C-terminal; IMG reference gene:2504772960; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; competence/damage-inducible protein CinA C-termina [...]
    
 0.937
AEE49495.1
5'-Nucleotidase domain-containing protein; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843:IPR008334; KEGG: ava:Ava_3996 metallophosphoesterase; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; SPTR: Metallophosphoesterase; IMG reference gene:2504770965; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain; Belongs to the 5'-nucleotidase family.
  
  
 0.927
AEE50577.1
COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase; InterPro IPR004393:IPR002638; KEGG: lby:Lbys_2650 nicotinate-nucleotide pyrophosphorylase (carboxylating); PFAM: Quinolinate phosphoribosyl transferase; PRIAM: Nicotinate-nucleotide diphosphorylase (carboxylating); SPTR: Nicotinate-nucleotide diphosphorylase; TIGRFAM: Nicotinate-nucleotide pyrophosphorylase; IMG reference gene:2504772080; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/Mo [...]
     
 0.927
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
     
 0.927
AEE53950.1
COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843; KEGG: sli:Slin_4342 metallophosphoesterase; PFAM: Metallophosphoesterase; PRIAM: 5'-nucleotidase; SPTR: Metallophosphoesterase; IMG reference gene:2504775530; PFAM: Calcineurin-like phosphoesterase.
     
 0.906
AEE48151.1
COGs: COG3201 Nicotinamide mononucleotide transporter; InterPro IPR006419; KEGG: gym:GYMC10_6275 nicotinamide mononucleotide transporter PnuC; PFAM: Nicotinamide mononucleotide transporter PnuC; SPTR: Nicotinamide mononucleotide transporter PnuC; TIGRFAM: Nicotinamide mononucleotide transporter PnuC; IMG reference gene:2504769590; PFAM: Nicotinamide mononucleotide transporter; TIGRFAM: nicotinamide mononucleotide transporter PnuC.
 
   
 0.901
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.