fit to screen
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEE48167.1Ferredoxin; COGs: COG0633 Ferredoxin; InterPro IPR001041; KEGG: phe:Phep_3215 ferredoxin; PFAM: Ferredoxin; SPTR: Ferredoxin; IMG reference gene:2504769607; PFAM: 2Fe-2S iron-sulfur cluster binding domain. (114 aa)    
Predicted Functional Partners:
AEE48168.1
FeS assembly protein IscX; InterPro IPR007479; KEGG: phe:Phep_3214 FeS assembly protein IscX; PFAM: ISC system FeS cluster assembly, IscX; SPTR: FeS assembly protein IscX; TIGRFAM: ISC system FeS cluster assembly, IscX; IMG reference gene:2504769608; PFAM: Protein of unknown function (DUF528); TIGRFAM: FeS assembly protein IscX.
 
  
 0.924
AEE53153.1
NADH dehydrogenase (quinone); COGs: COG1894 NADH:ubiquinone oxidoreductase NADH-binding (51 kD) subunit; InterPro IPR011538:IPR019554:IPR019575; KEGG: pub:SAR11_0680 NAD-dependent formate dehydrogenase subunit beta; PFAM: NADH:ubiquinone oxidoreductase, 51kDa subunit; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; PRIAM: NADH dehydrogenase (quinone); SPTR: NAD-dependent formate dehydrogenase beta subunit; IMG reference gene:2504774726; PFAM: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Respiratory-chain NADH dehydrogenase [...]
  
 
 0.918
AEE49237.1
FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 0.906
AEE51522.1
COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR001450; KEGG: gpb:HDN1F_09540 2-ketoglutarate: NADP oxidoreductase, gamma subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; PRIAM: Glutamate synthase (NADPH); SPTR: 4Fe-4S binding domain protein; IMG reference gene:2504773051; PFAM: Pyridine nucleotide-disulphide oxidoreductase.
  
 0.895
iscS
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
 
 0.884
AEE48184.1
Co-chaperone Hsc20; InterPro IPR001623:IPR009073:IPR004640; KEGG: phe:Phep_3175 co-chaperone Hsc20; PFAM: Heat shock protein DnaJ, N-terminal; Heat shock cognate protein B, C-terminal oligomerisation; SPTR: Co-chaperone Hsc20; TIGRFAM: Co-chaperone Hsc20; IMG reference gene:2504769625; PFAM: DnaJ domain; HSCB C-terminal oligomerisation domain; TIGRFAM: Fe-S protein assembly co-chaperone HscB.
 
  
 0.811
AEE53631.1
COGs: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; InterPro IPR000192; KEGG: cpi:Cpin_1845 cysteine desulfurase; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Cysteine desulfurase; SPTR: Cysteine desulfurase; IMG reference gene:2504775206; PFAM: Aminotransferase class-V.
 
 0.664
AEE54184.1
SUF system FeS assembly protein, NifU family; COGs: COG0822 NifU homolog involved in Fe-S cluster formation; InterPro IPR011341:IPR002871; KEGG: tmz:Tmz1t_1895 SUF system FeS assembly protein, NifU family; PFAM: NIF system FeS cluster assembly, NifU, N-terminal; SPTR: SUF system FeS assembly protein, NifU family; TIGRFAM: SUF system FeS cluster assembly, SufU scaffold; IMG reference gene:2504775773; PFAM: NifU-like N terminal domain; TIGRFAM: SUF system FeS assembly protein, NifU family.
  
 0.635
AEE48169.1
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; COGs: COG1778 Low specificity phosphatase (HAD superfamily); InterPro IPR010023:IPR006549; KEGG: gfo:GFO_1811 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; SPTR: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; TIGRFAM: Phosphatase KdsC; HAD-superfamily hydrolase, subfamily IIIA; IMG reference gene:2504769609; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family.
       0.610
nuoD
NAD(P)H-quinone oxidoreductase subunit H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family.
  
 
 0.575
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.