| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEE48199.1 | AEE48200.1 | Halhy_0287 | Halhy_0288 | tRNA 2-selenouridine synthase; COGs: COG2603 ATPase; InterPro IPR001763:IPR017582; KEGG: sli:Slin_4991 tRNA 2-selenouridine synthase; PFAM: Rhodanese-like; SMART: Rhodanese-like; SPTR: tRNA 2-selenouridine synthase; TIGRFAM: tRNA 2-selenouridine synthase; IMG reference gene:2504769642; PFAM: Rhodanese-like domain; TIGRFAM: tRNA 2-selenouridine synthase. | COGs: COG0408 Coproporphyrinogen III oxidase; InterPro IPR001260; KEGG: dfe:Dfer_2369 coproporphyrinogen III oxidase; PFAM: Coproporphyrinogen III oxidase; PRIAM: Coproporphyrinogen oxidase; SPTR: Coproporphyrinogen oxidase; IMG reference gene:2504769643; PFAM: Coproporphyrinogen III oxidase. | 0.773 |
| AEE48199.1 | selD | Halhy_0287 | Halhy_0286 | tRNA 2-selenouridine synthase; COGs: COG2603 ATPase; InterPro IPR001763:IPR017582; KEGG: sli:Slin_4991 tRNA 2-selenouridine synthase; PFAM: Rhodanese-like; SMART: Rhodanese-like; SPTR: tRNA 2-selenouridine synthase; TIGRFAM: tRNA 2-selenouridine synthase; IMG reference gene:2504769642; PFAM: Rhodanese-like domain; TIGRFAM: tRNA 2-selenouridine synthase. | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.965 |
| AEE48200.1 | AEE48199.1 | Halhy_0288 | Halhy_0287 | COGs: COG0408 Coproporphyrinogen III oxidase; InterPro IPR001260; KEGG: dfe:Dfer_2369 coproporphyrinogen III oxidase; PFAM: Coproporphyrinogen III oxidase; PRIAM: Coproporphyrinogen oxidase; SPTR: Coproporphyrinogen oxidase; IMG reference gene:2504769643; PFAM: Coproporphyrinogen III oxidase. | tRNA 2-selenouridine synthase; COGs: COG2603 ATPase; InterPro IPR001763:IPR017582; KEGG: sli:Slin_4991 tRNA 2-selenouridine synthase; PFAM: Rhodanese-like; SMART: Rhodanese-like; SPTR: tRNA 2-selenouridine synthase; TIGRFAM: tRNA 2-selenouridine synthase; IMG reference gene:2504769642; PFAM: Rhodanese-like domain; TIGRFAM: tRNA 2-selenouridine synthase. | 0.773 |
| AEE48200.1 | AEE49007.1 | Halhy_0288 | Halhy_1109 | COGs: COG0408 Coproporphyrinogen III oxidase; InterPro IPR001260; KEGG: dfe:Dfer_2369 coproporphyrinogen III oxidase; PFAM: Coproporphyrinogen III oxidase; PRIAM: Coproporphyrinogen oxidase; SPTR: Coproporphyrinogen oxidase; IMG reference gene:2504769643; PFAM: Coproporphyrinogen III oxidase. | Radical SAM domain protein; COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR007197:IPR010723:IPR006638; KEGG: hau:Haur_1841 coproporphyrinogen III oxidase; PFAM: Radical SAM; HemN, C-terminal; SMART: Elongator protein 3/MiaB/NifB; SPTR: Coproporphyrinogen III oxidase family protein; IMG reference gene:2504770470; PFAM: Radical SAM superfamily; HemN C-terminal region. | 0.916 |
| AEE48200.1 | AEE51303.1 | Halhy_0288 | Halhy_3447 | COGs: COG0408 Coproporphyrinogen III oxidase; InterPro IPR001260; KEGG: dfe:Dfer_2369 coproporphyrinogen III oxidase; PFAM: Coproporphyrinogen III oxidase; PRIAM: Coproporphyrinogen oxidase; SPTR: Coproporphyrinogen oxidase; IMG reference gene:2504769643; PFAM: Coproporphyrinogen III oxidase. | COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR006638:IPR004558:IPR007197:IPR010723; KEGG: cpi:Cpin_0687 coproporphyrinogen III oxidase; PFAM: HemN, C-terminal; Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Oxygen-independent coproporphyrinogen III oxidase; TIGRFAM: Oxygen-independent coproporphyrinogen III oxidase HemN; IMG reference gene:2504772828; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.926 |
| AEE48200.1 | AEE51541.1 | Halhy_0288 | Halhy_3689 | COGs: COG0408 Coproporphyrinogen III oxidase; InterPro IPR001260; KEGG: dfe:Dfer_2369 coproporphyrinogen III oxidase; PFAM: Coproporphyrinogen III oxidase; PRIAM: Coproporphyrinogen oxidase; SPTR: Coproporphyrinogen oxidase; IMG reference gene:2504769643; PFAM: Coproporphyrinogen III oxidase. | Uncharacterized protein family UPF0093; COGs: COG1981 membrane protein; InterPro IPR005265; KEGG: lby:Lbys_1279 uncharacterized protein family upf0093; PFAM: Uncharacterised protein family UPF0093; SPTR: Uncharacterized protein family UPF0093; IMG reference gene:2504773070; PFAM: Uncharacterised protein family (UPF0093); TIGRFAM: TIGR00701 family protein. | 0.950 |
| AEE48200.1 | AEE52331.1 | Halhy_0288 | Halhy_4491 | COGs: COG0408 Coproporphyrinogen III oxidase; InterPro IPR001260; KEGG: dfe:Dfer_2369 coproporphyrinogen III oxidase; PFAM: Coproporphyrinogen III oxidase; PRIAM: Coproporphyrinogen oxidase; SPTR: Coproporphyrinogen oxidase; IMG reference gene:2504769643; PFAM: Coproporphyrinogen III oxidase. | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: sli:Slin_5386 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Porphobilinogen synthase; manually curated; IMG reference gene:2504773878; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.582 |
| AEE48200.1 | AEE52545.1 | Halhy_0288 | Halhy_4711 | COGs: COG0408 Coproporphyrinogen III oxidase; InterPro IPR001260; KEGG: dfe:Dfer_2369 coproporphyrinogen III oxidase; PFAM: Coproporphyrinogen III oxidase; PRIAM: Coproporphyrinogen oxidase; SPTR: Coproporphyrinogen oxidase; IMG reference gene:2504769643; PFAM: Coproporphyrinogen III oxidase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.575 |
| AEE48200.1 | hemE | Halhy_0288 | Halhy_5610 | COGs: COG0408 Coproporphyrinogen III oxidase; InterPro IPR001260; KEGG: dfe:Dfer_2369 coproporphyrinogen III oxidase; PFAM: Coproporphyrinogen III oxidase; PRIAM: Coproporphyrinogen oxidase; SPTR: Coproporphyrinogen oxidase; IMG reference gene:2504769643; PFAM: Coproporphyrinogen III oxidase. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.973 |
| AEE48200.1 | hemH | Halhy_0288 | Halhy_5067 | COGs: COG0408 Coproporphyrinogen III oxidase; InterPro IPR001260; KEGG: dfe:Dfer_2369 coproporphyrinogen III oxidase; PFAM: Coproporphyrinogen III oxidase; PRIAM: Coproporphyrinogen oxidase; SPTR: Coproporphyrinogen oxidase; IMG reference gene:2504769643; PFAM: Coproporphyrinogen III oxidase. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.764 |
| AEE48200.1 | nadD | Halhy_0288 | Halhy_3374 | COGs: COG0408 Coproporphyrinogen III oxidase; InterPro IPR001260; KEGG: dfe:Dfer_2369 coproporphyrinogen III oxidase; PFAM: Coproporphyrinogen III oxidase; PRIAM: Coproporphyrinogen oxidase; SPTR: Coproporphyrinogen oxidase; IMG reference gene:2504769643; PFAM: Coproporphyrinogen III oxidase. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.482 |
| AEE48200.1 | selD | Halhy_0288 | Halhy_0286 | COGs: COG0408 Coproporphyrinogen III oxidase; InterPro IPR001260; KEGG: dfe:Dfer_2369 coproporphyrinogen III oxidase; PFAM: Coproporphyrinogen III oxidase; PRIAM: Coproporphyrinogen oxidase; SPTR: Coproporphyrinogen oxidase; IMG reference gene:2504769643; PFAM: Coproporphyrinogen III oxidase. | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.773 |
| AEE49007.1 | AEE48200.1 | Halhy_1109 | Halhy_0288 | Radical SAM domain protein; COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR007197:IPR010723:IPR006638; KEGG: hau:Haur_1841 coproporphyrinogen III oxidase; PFAM: Radical SAM; HemN, C-terminal; SMART: Elongator protein 3/MiaB/NifB; SPTR: Coproporphyrinogen III oxidase family protein; IMG reference gene:2504770470; PFAM: Radical SAM superfamily; HemN C-terminal region. | COGs: COG0408 Coproporphyrinogen III oxidase; InterPro IPR001260; KEGG: dfe:Dfer_2369 coproporphyrinogen III oxidase; PFAM: Coproporphyrinogen III oxidase; PRIAM: Coproporphyrinogen oxidase; SPTR: Coproporphyrinogen oxidase; IMG reference gene:2504769643; PFAM: Coproporphyrinogen III oxidase. | 0.916 |
| AEE49007.1 | AEE51303.1 | Halhy_1109 | Halhy_3447 | Radical SAM domain protein; COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR007197:IPR010723:IPR006638; KEGG: hau:Haur_1841 coproporphyrinogen III oxidase; PFAM: Radical SAM; HemN, C-terminal; SMART: Elongator protein 3/MiaB/NifB; SPTR: Coproporphyrinogen III oxidase family protein; IMG reference gene:2504770470; PFAM: Radical SAM superfamily; HemN C-terminal region. | COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR006638:IPR004558:IPR007197:IPR010723; KEGG: cpi:Cpin_0687 coproporphyrinogen III oxidase; PFAM: HemN, C-terminal; Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Oxygen-independent coproporphyrinogen III oxidase; TIGRFAM: Oxygen-independent coproporphyrinogen III oxidase HemN; IMG reference gene:2504772828; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.913 |
| AEE49007.1 | AEE51541.1 | Halhy_1109 | Halhy_3689 | Radical SAM domain protein; COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR007197:IPR010723:IPR006638; KEGG: hau:Haur_1841 coproporphyrinogen III oxidase; PFAM: Radical SAM; HemN, C-terminal; SMART: Elongator protein 3/MiaB/NifB; SPTR: Coproporphyrinogen III oxidase family protein; IMG reference gene:2504770470; PFAM: Radical SAM superfamily; HemN C-terminal region. | Uncharacterized protein family UPF0093; COGs: COG1981 membrane protein; InterPro IPR005265; KEGG: lby:Lbys_1279 uncharacterized protein family upf0093; PFAM: Uncharacterised protein family UPF0093; SPTR: Uncharacterized protein family UPF0093; IMG reference gene:2504773070; PFAM: Uncharacterised protein family (UPF0093); TIGRFAM: TIGR00701 family protein. | 0.918 |
| AEE49007.1 | hemE | Halhy_1109 | Halhy_5610 | Radical SAM domain protein; COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR007197:IPR010723:IPR006638; KEGG: hau:Haur_1841 coproporphyrinogen III oxidase; PFAM: Radical SAM; HemN, C-terminal; SMART: Elongator protein 3/MiaB/NifB; SPTR: Coproporphyrinogen III oxidase family protein; IMG reference gene:2504770470; PFAM: Radical SAM superfamily; HemN C-terminal region. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.921 |
| AEE51303.1 | AEE48200.1 | Halhy_3447 | Halhy_0288 | COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR006638:IPR004558:IPR007197:IPR010723; KEGG: cpi:Cpin_0687 coproporphyrinogen III oxidase; PFAM: HemN, C-terminal; Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Oxygen-independent coproporphyrinogen III oxidase; TIGRFAM: Oxygen-independent coproporphyrinogen III oxidase HemN; IMG reference gene:2504772828; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | COGs: COG0408 Coproporphyrinogen III oxidase; InterPro IPR001260; KEGG: dfe:Dfer_2369 coproporphyrinogen III oxidase; PFAM: Coproporphyrinogen III oxidase; PRIAM: Coproporphyrinogen oxidase; SPTR: Coproporphyrinogen oxidase; IMG reference gene:2504769643; PFAM: Coproporphyrinogen III oxidase. | 0.926 |
| AEE51303.1 | AEE49007.1 | Halhy_3447 | Halhy_1109 | COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR006638:IPR004558:IPR007197:IPR010723; KEGG: cpi:Cpin_0687 coproporphyrinogen III oxidase; PFAM: HemN, C-terminal; Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Oxygen-independent coproporphyrinogen III oxidase; TIGRFAM: Oxygen-independent coproporphyrinogen III oxidase HemN; IMG reference gene:2504772828; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Radical SAM domain protein; COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR007197:IPR010723:IPR006638; KEGG: hau:Haur_1841 coproporphyrinogen III oxidase; PFAM: Radical SAM; HemN, C-terminal; SMART: Elongator protein 3/MiaB/NifB; SPTR: Coproporphyrinogen III oxidase family protein; IMG reference gene:2504770470; PFAM: Radical SAM superfamily; HemN C-terminal region. | 0.913 |
| AEE51303.1 | AEE51541.1 | Halhy_3447 | Halhy_3689 | COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR006638:IPR004558:IPR007197:IPR010723; KEGG: cpi:Cpin_0687 coproporphyrinogen III oxidase; PFAM: HemN, C-terminal; Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Oxygen-independent coproporphyrinogen III oxidase; TIGRFAM: Oxygen-independent coproporphyrinogen III oxidase HemN; IMG reference gene:2504772828; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Uncharacterized protein family UPF0093; COGs: COG1981 membrane protein; InterPro IPR005265; KEGG: lby:Lbys_1279 uncharacterized protein family upf0093; PFAM: Uncharacterised protein family UPF0093; SPTR: Uncharacterized protein family UPF0093; IMG reference gene:2504773070; PFAM: Uncharacterised protein family (UPF0093); TIGRFAM: TIGR00701 family protein. | 0.930 |
| AEE51303.1 | hemE | Halhy_3447 | Halhy_5610 | COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR006638:IPR004558:IPR007197:IPR010723; KEGG: cpi:Cpin_0687 coproporphyrinogen III oxidase; PFAM: HemN, C-terminal; Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Oxygen-independent coproporphyrinogen III oxidase; TIGRFAM: Oxygen-independent coproporphyrinogen III oxidase HemN; IMG reference gene:2504772828; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.954 |