| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEE49498.1 | AEE49983.1 | Halhy_1607 | Halhy_2098 | COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cystathionine beta-synthase; IMG reference gene:2504770968; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.935 |
| AEE49498.1 | AEE50854.1 | Halhy_1607 | Halhy_2990 | COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cystathionine beta-synthase; IMG reference gene:2504770968; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | COGs: COG0527 Aspartokinase; InterProIPR001048:IPR002912:IPR005106:IPR001342:IPR 001341; KEGG: chu:CHU_0073 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Aspartate/homoserine dehydrogenase, NAD-binding; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: Bifunctional protein: aspartokinase I; homoserine dehydrogenase; TIGRFAM: Aspartate kinase region; IMG reference gene:2504772364; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT dom [...] | 0.865 |
| AEE49498.1 | AEE51689.1 | Halhy_1607 | Halhy_3837 | COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cystathionine beta-synthase; IMG reference gene:2504770968; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR006235:IPR000277; KEGG: chu:CHU_0274 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PRIAM: Cysteine synthase; SPTR: O-acetylhomoserine sulfhydrolase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; IMG reference gene:2504773221; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | 0.933 |
| AEE49498.1 | AEE52157.1 | Halhy_1607 | Halhy_4313 | COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cystathionine beta-synthase; IMG reference gene:2504770968; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_5820 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504773699; PFAM: Cobalamin-independent synthase, Catalytic domain. | 0.909 |
| AEE49498.1 | AEE53253.1 | Halhy_1607 | Halhy_5428 | COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cystathionine beta-synthase; IMG reference gene:2504770968; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR000277; KEGG: rca:Rcas_3473 cystathionine gamma-synthase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; SPTR: Cystathionine gamma-synthase; IMG reference gene:2504774826; PFAM: Cys/Met metabolism PLP-dependent enzyme. | 0.969 |
| AEE49498.1 | AEE53707.1 | Halhy_1607 | Halhy_5884 | COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cystathionine beta-synthase; IMG reference gene:2504770968; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | COGs: COG0155 Sulfite reductase beta subunit (hemoprotein); InterPro IPR005117:IPR006067; KEGG: chu:CHU_2637 sulfite reductase (NADPH); PFAM: Nitrite/sulphite reductase 4Fe-4S region; Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like; PRIAM: Ferredoxin--nitrite reductase; SPTR: Sulfite reductase (NADPH); IMG reference gene:2504775282; PFAM: HEPN domain; Nitrite and sulphite reductase 4Fe-4S domain; Nitrite/Sulfite reductase ferredoxin-like half domain. | 0.428 |
| AEE49498.1 | AEE54139.1 | Halhy_1607 | Halhy_6320 | COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cystathionine beta-synthase; IMG reference gene:2504770968; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | COGs: COG0031 Cysteine synthase; InterPro IPR001926:IPR000644; KEGG: phe:Phep_1434 cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Cystathionine beta-synthase, core; PRIAM: Cysteine synthase; SMART: Cystathionine beta-synthase, core; SPTR: Cystathionine beta-synthase; IMG reference gene:2504775728; PFAM: CBS domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | 0.903 |
| AEE49498.1 | ahcY | Halhy_1607 | Halhy_1875 | COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cystathionine beta-synthase; IMG reference gene:2504770968; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.921 |
| AEE49498.1 | metXA | Halhy_1607 | Halhy_5551 | COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cystathionine beta-synthase; IMG reference gene:2504770968; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.830 |
| AEE49498.1 | metZ | Halhy_1607 | Halhy_0430 | COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cystathionine beta-synthase; IMG reference gene:2504770968; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | Cystathionine gamma-lyase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.961 |
| AEE49983.1 | AEE49498.1 | Halhy_2098 | Halhy_1607 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cystathionine beta-synthase; IMG reference gene:2504770968; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | 0.935 |
| AEE49983.1 | AEE50854.1 | Halhy_2098 | Halhy_2990 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COGs: COG0527 Aspartokinase; InterProIPR001048:IPR002912:IPR005106:IPR001342:IPR 001341; KEGG: chu:CHU_0073 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Aspartate/homoserine dehydrogenase, NAD-binding; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: Bifunctional protein: aspartokinase I; homoserine dehydrogenase; TIGRFAM: Aspartate kinase region; IMG reference gene:2504772364; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT dom [...] | 0.958 |
| AEE49983.1 | AEE51689.1 | Halhy_2098 | Halhy_3837 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR006235:IPR000277; KEGG: chu:CHU_0274 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PRIAM: Cysteine synthase; SPTR: O-acetylhomoserine sulfhydrolase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; IMG reference gene:2504773221; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | 0.949 |
| AEE49983.1 | AEE52157.1 | Halhy_2098 | Halhy_4313 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_5820 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504773699; PFAM: Cobalamin-independent synthase, Catalytic domain. | 0.968 |
| AEE49983.1 | AEE53253.1 | Halhy_2098 | Halhy_5428 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR000277; KEGG: rca:Rcas_3473 cystathionine gamma-synthase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; SPTR: Cystathionine gamma-synthase; IMG reference gene:2504774826; PFAM: Cys/Met metabolism PLP-dependent enzyme. | 0.963 |
| AEE49983.1 | AEE53707.1 | Halhy_2098 | Halhy_5884 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COGs: COG0155 Sulfite reductase beta subunit (hemoprotein); InterPro IPR005117:IPR006067; KEGG: chu:CHU_2637 sulfite reductase (NADPH); PFAM: Nitrite/sulphite reductase 4Fe-4S region; Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like; PRIAM: Ferredoxin--nitrite reductase; SPTR: Sulfite reductase (NADPH); IMG reference gene:2504775282; PFAM: HEPN domain; Nitrite and sulphite reductase 4Fe-4S domain; Nitrite/Sulfite reductase ferredoxin-like half domain. | 0.448 |
| AEE49983.1 | AEE54139.1 | Halhy_2098 | Halhy_6320 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COGs: COG0031 Cysteine synthase; InterPro IPR001926:IPR000644; KEGG: phe:Phep_1434 cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Cystathionine beta-synthase, core; PRIAM: Cysteine synthase; SMART: Cystathionine beta-synthase, core; SPTR: Cystathionine beta-synthase; IMG reference gene:2504775728; PFAM: CBS domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase. | 0.937 |
| AEE49983.1 | ahcY | Halhy_2098 | Halhy_1875 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.947 |
| AEE49983.1 | metXA | Halhy_2098 | Halhy_5551 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.694 |
| AEE49983.1 | metZ | Halhy_2098 | Halhy_0430 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine gamma-lyase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.963 |
