| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEE48374.1 | AEE48375.1 | Halhy_0464 | Halhy_0465 | KEGG: sli:Slin_1558 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504769820. | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_1559 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504769821; PFAM: Cobalamin-independent synthase, Catalytic domain. | 0.514 |
| AEE48374.1 | AEE48377.1 | Halhy_0464 | Halhy_0467 | KEGG: sli:Slin_1558 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504769820. | FAD dependent oxidoreductase; COGs: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase; InterPro IPR006076; KEGG: sli:Slin_0336 monooxygenase FAD-binding protein; PFAM: FAD dependent oxidoreductase; SPTR: Monooxygenase FAD-binding protein; IMG reference gene:2504769823; PFAM: FAD binding domain. | 0.539 |
| AEE48375.1 | AEE48374.1 | Halhy_0465 | Halhy_0464 | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_1559 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504769821; PFAM: Cobalamin-independent synthase, Catalytic domain. | KEGG: sli:Slin_1558 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504769820. | 0.514 |
| AEE48375.1 | AEE48377.1 | Halhy_0465 | Halhy_0467 | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_1559 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504769821; PFAM: Cobalamin-independent synthase, Catalytic domain. | FAD dependent oxidoreductase; COGs: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase; InterPro IPR006076; KEGG: sli:Slin_0336 monooxygenase FAD-binding protein; PFAM: FAD dependent oxidoreductase; SPTR: Monooxygenase FAD-binding protein; IMG reference gene:2504769823; PFAM: FAD binding domain. | 0.515 |
| AEE48375.1 | AEE49080.1 | Halhy_0465 | Halhy_1183 | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_1559 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504769821; PFAM: Cobalamin-independent synthase, Catalytic domain. | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: chu:CHU_3776 glutamate synthase (NADH) large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (NADH) large subunit; IMG reference gene:2504770544; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | 0.521 |
| AEE48375.1 | AEE49983.1 | Halhy_0465 | Halhy_2098 | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_1559 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504769821; PFAM: Cobalamin-independent synthase, Catalytic domain. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.700 |
| AEE48375.1 | AEE50513.1 | Halhy_0465 | Halhy_2644 | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_1559 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504769821; PFAM: Cobalamin-independent synthase, Catalytic domain. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR004620:IPR003171; KEGG: mtt:Ftrac_3624 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: Methylenetetrahydrofolate reductase (NAD(P)H); TIGRFAM: 5,10-methylenetetrahydrofolate reductase; IMG reference gene:2504772015; PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family. | 0.784 |
| AEE48375.1 | AEE50854.1 | Halhy_0465 | Halhy_2990 | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_1559 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504769821; PFAM: Cobalamin-independent synthase, Catalytic domain. | COGs: COG0527 Aspartokinase; InterProIPR001048:IPR002912:IPR005106:IPR001342:IPR 001341; KEGG: chu:CHU_0073 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Aspartate/homoserine dehydrogenase, NAD-binding; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: Bifunctional protein: aspartokinase I; homoserine dehydrogenase; TIGRFAM: Aspartate kinase region; IMG reference gene:2504772364; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT dom [...] | 0.638 |
| AEE48375.1 | AEE51689.1 | Halhy_0465 | Halhy_3837 | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_1559 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504769821; PFAM: Cobalamin-independent synthase, Catalytic domain. | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR006235:IPR000277; KEGG: chu:CHU_0274 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PRIAM: Cysteine synthase; SPTR: O-acetylhomoserine sulfhydrolase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; IMG reference gene:2504773221; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | 0.624 |
| AEE48375.1 | AEE52827.1 | Halhy_0465 | Halhy_4999 | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_1559 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504769821; PFAM: Cobalamin-independent synthase, Catalytic domain. | 3-carboxy-cis,cis-muconate cycloisomerase; COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362:IPR019468:IPR012789; KEGG: avn:Avin_38190 3-carboxy-cis,cis-muconate cycloisomerase; PFAM: Fumarate lyase; Adenylosuccinate lyase, C-terminal; PRIAM: 3-carboxy-cis,cis-muconate cycloisomerase; SPTR: 3-carboxy-cis,cis-muconate cycloisomerase; TIGRFAM: 3-carboxy-cis,cis-muconate cycloisomerase; IMG reference gene:2504774394; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: 3-carboxy-cis,cis-muconate cycloisomerase. | 0.551 |
| AEE48375.1 | ahcY | Halhy_0465 | Halhy_1875 | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_1559 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504769821; PFAM: Cobalamin-independent synthase, Catalytic domain. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.776 |
| AEE48375.1 | metK | Halhy_0465 | Halhy_4474 | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_1559 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504769821; PFAM: Cobalamin-independent synthase, Catalytic domain. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.838 |
| AEE48377.1 | AEE48374.1 | Halhy_0467 | Halhy_0464 | FAD dependent oxidoreductase; COGs: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase; InterPro IPR006076; KEGG: sli:Slin_0336 monooxygenase FAD-binding protein; PFAM: FAD dependent oxidoreductase; SPTR: Monooxygenase FAD-binding protein; IMG reference gene:2504769823; PFAM: FAD binding domain. | KEGG: sli:Slin_1558 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504769820. | 0.539 |
| AEE48377.1 | AEE48375.1 | Halhy_0467 | Halhy_0465 | FAD dependent oxidoreductase; COGs: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase; InterPro IPR006076; KEGG: sli:Slin_0336 monooxygenase FAD-binding protein; PFAM: FAD dependent oxidoreductase; SPTR: Monooxygenase FAD-binding protein; IMG reference gene:2504769823; PFAM: FAD binding domain. | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_1559 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504769821; PFAM: Cobalamin-independent synthase, Catalytic domain. | 0.515 |
| AEE48377.1 | AEE52827.1 | Halhy_0467 | Halhy_4999 | FAD dependent oxidoreductase; COGs: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase; InterPro IPR006076; KEGG: sli:Slin_0336 monooxygenase FAD-binding protein; PFAM: FAD dependent oxidoreductase; SPTR: Monooxygenase FAD-binding protein; IMG reference gene:2504769823; PFAM: FAD binding domain. | 3-carboxy-cis,cis-muconate cycloisomerase; COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362:IPR019468:IPR012789; KEGG: avn:Avin_38190 3-carboxy-cis,cis-muconate cycloisomerase; PFAM: Fumarate lyase; Adenylosuccinate lyase, C-terminal; PRIAM: 3-carboxy-cis,cis-muconate cycloisomerase; SPTR: 3-carboxy-cis,cis-muconate cycloisomerase; TIGRFAM: 3-carboxy-cis,cis-muconate cycloisomerase; IMG reference gene:2504774394; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: 3-carboxy-cis,cis-muconate cycloisomerase. | 0.500 |
| AEE49080.1 | AEE48375.1 | Halhy_1183 | Halhy_0465 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: chu:CHU_3776 glutamate synthase (NADH) large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (NADH) large subunit; IMG reference gene:2504770544; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_1559 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504769821; PFAM: Cobalamin-independent synthase, Catalytic domain. | 0.521 |
| AEE49080.1 | AEE50513.1 | Halhy_1183 | Halhy_2644 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: chu:CHU_3776 glutamate synthase (NADH) large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (NADH) large subunit; IMG reference gene:2504770544; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR004620:IPR003171; KEGG: mtt:Ftrac_3624 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: Methylenetetrahydrofolate reductase (NAD(P)H); TIGRFAM: 5,10-methylenetetrahydrofolate reductase; IMG reference gene:2504772015; PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family. | 0.536 |
| AEE49080.1 | AEE50854.1 | Halhy_1183 | Halhy_2990 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: chu:CHU_3776 glutamate synthase (NADH) large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (NADH) large subunit; IMG reference gene:2504770544; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | COGs: COG0527 Aspartokinase; InterProIPR001048:IPR002912:IPR005106:IPR001342:IPR 001341; KEGG: chu:CHU_0073 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Aspartate/homoserine dehydrogenase, NAD-binding; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: Bifunctional protein: aspartokinase I; homoserine dehydrogenase; TIGRFAM: Aspartate kinase region; IMG reference gene:2504772364; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT dom [...] | 0.716 |
| AEE49080.1 | AEE52827.1 | Halhy_1183 | Halhy_4999 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: chu:CHU_3776 glutamate synthase (NADH) large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (NADH) large subunit; IMG reference gene:2504770544; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | 3-carboxy-cis,cis-muconate cycloisomerase; COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362:IPR019468:IPR012789; KEGG: avn:Avin_38190 3-carboxy-cis,cis-muconate cycloisomerase; PFAM: Fumarate lyase; Adenylosuccinate lyase, C-terminal; PRIAM: 3-carboxy-cis,cis-muconate cycloisomerase; SPTR: 3-carboxy-cis,cis-muconate cycloisomerase; TIGRFAM: 3-carboxy-cis,cis-muconate cycloisomerase; IMG reference gene:2504774394; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: 3-carboxy-cis,cis-muconate cycloisomerase. | 0.474 |
| AEE49983.1 | AEE48375.1 | Halhy_2098 | Halhy_0465 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_1559 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504769821; PFAM: Cobalamin-independent synthase, Catalytic domain. | 0.700 |