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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEE48572.1Adenylate/guanylate cyclase with TPR repeats; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterProIPR003018:IPR013656:IPR001054:IPR013105:IPR 000014; KEGG: dsa:Desal_0985 adenylate/guanylate cyclase with GAF and PAS/PAC sensors; PFAM: Adenylyl cyclase class-3/4/guanylyl cyclase; GAF; PAS fold-4; Tetratricopeptide TPR2; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase; GAF; PAS; SPTR: Adenylate/guanylate cyclase with GAF and PAS/PAC sensors; TIGRFAM: PAS; IMG reference gene:2504770022; PFAM: Adenylate and Guanylate cyclase catalytic domain; GAF domain; [...] (724 aa)    
Predicted Functional Partners:
AEE52553.1
Metallophosphoesterase; COGs: COG1409 phosphohydrolase; InterPro IPR004843; KEGG: sli:Slin_1191 metallophosphoesterase; PFAM: Metallophosphoesterase; SPTR: Metallophosphoesterase; IMG reference gene:2504774111; PFAM: Calcineurin-like phosphoesterase.
    
 0.917
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.910
AEE50870.1
COGs: COG0469 Pyruvate kinase; InterPro IPR015793:IPR015794:IPR001697; KEGG: cpi:Cpin_2321 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; PRIAM: Pyruvate kinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; IMG reference gene:2504772381; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
    
 0.902
AEE53641.1
COGs: COG0469 Pyruvate kinase; InterPro IPR015793; KEGG: pyruvate kinase; PFAM: Pyruvate kinase, barrel; PRIAM: Pyruvate kinase; SPTR: Pyruvate kinase; IMG reference gene:2504775216; PFAM: Pyruvate kinase, barrel domain; Belongs to the pyruvate kinase family.
    
 0.902
AEE48578.1
Putative transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR000595; KEGG: cyn:Cyan7425_1753 cyclic nucleotide-binding protein; PFAM: Cyclic nucleotide-binding; SMART: Cyclic nucleotide-binding; SPTR: Putative uncharacterized protein; IMG reference gene:2504770028; PFAM: Cyclic nucleotide-binding domain.
 
 0.825
ribB
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
    
  0.825
folE
COGs: COG0302 GTP cyclohydrolase I; HAMAP: GTP cyclohydrolase I; InterPro IPR001474:IPR020602; KEGG: cts:Ctha_0487 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: GTP cyclohydrolase 1 2; TIGRFAM: GTP cyclohydrolase I; IMG reference gene:2504770198; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I.
    
  0.809
ribA
GTP cyclohydrolase-2; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.
    
  0.803
AEE54242.1
COGs: COG0807 GTP cyclohydrolase II; InterPro IPR000926; KEGG: dev:DhcVS_971 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; PFAM: GTP cyclohydrolase II; PRIAM: GTP cyclohydrolase II; SPTR: 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II; IMG reference gene:2504775832; PFAM: GTP cyclohydrolase II; TIGRFAM: GTP cyclohydrolase II.
    
  0.803
AEE48573.1
KEGG: ava:Ava_1135 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504770023.
       0.773
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
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