Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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AEE48572.1Adenylate/guanylate cyclase with TPR repeats; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterProIPR003018:IPR013656:IPR001054:IPR013105:IPR 000014; KEGG: dsa:Desal_0985 adenylate/guanylate cyclase with GAF and PAS/PAC sensors; PFAM: Adenylyl cyclase class-3/4/guanylyl cyclase; GAF; PAS fold-4; Tetratricopeptide TPR2; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase; GAF; PAS; SPTR: Adenylate/guanylate cyclase with GAF and PAS/PAC sensors; TIGRFAM: PAS; IMG reference gene:2504770022; PFAM: Adenylate and Guanylate cyclase catalytic domain; GAF domain; [...] (724 aa)    
Predicted Functional Partners:
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
  0.905
AEE49861.1
Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
  
 
  0.824
ribB
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
    
  0.820
AEE48578.1
Putative transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR000595; KEGG: cyn:Cyan7425_1753 cyclic nucleotide-binding protein; PFAM: Cyclic nucleotide-binding; SMART: Cyclic nucleotide-binding; SPTR: Putative uncharacterized protein; IMG reference gene:2504770028; PFAM: Cyclic nucleotide-binding domain.
 
 
 0.815
folE
COGs: COG0302 GTP cyclohydrolase I; HAMAP: GTP cyclohydrolase I; InterPro IPR001474:IPR020602; KEGG: cts:Ctha_0487 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: GTP cyclohydrolase 1 2; TIGRFAM: GTP cyclohydrolase I; IMG reference gene:2504770198; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I.
    
  0.808
ribA
GTP cyclohydrolase-2; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.
    
  0.803
AEE54242.1
COGs: COG0807 GTP cyclohydrolase II; InterPro IPR000926; KEGG: dev:DhcVS_971 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; PFAM: GTP cyclohydrolase II; PRIAM: GTP cyclohydrolase II; SPTR: 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II; IMG reference gene:2504775832; PFAM: GTP cyclohydrolase II; TIGRFAM: GTP cyclohydrolase II.
    
  0.803
AEE48573.1
KEGG: ava:Ava_1135 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504770023.
       0.773
AEE48574.1
NHPM bacteriocin system ABC transporter, ATP-binding protein; COGs: COG2274 ABC-type bacteriocin/lantibiotic exporter contain an N-terminal double-glycine peptidase domain; InterPro IPR001140:IPR003439:IPR003593; KEGG: dbr:Deba_2499 ABC transporter related protein; PFAM: ABC transporter-like; ABC transporter, transmembrane region; PRIAM: Xenobiotic-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein; TIGRFAM: NHPM bacteriocin system ABC transporter, ATP-binding protein; IMG reference gene:2504770024; PFAM: ABC transporter; ABC transporter transmem [...]
       0.773
AEE48575.1
NHPM bacteriocin system ABC transporter, peptidase/ATP-binding protein; COGs: COG2274 ABC-type bacteriocin/lantibiotic exporter contain an N-terminal double-glycine peptidase domain; InterPro IPR005074:IPR001140:IPR003439:IPR003593; KEGG: dae:Dtox_0939 ABC transporter related; PFAM: ABC transporter-like; Peptidase C39, bacteriocin processing; ABC transporter, transmembrane region; PRIAM: Xenobiotic-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related; TIGRFAM: NHPM bacteriocin system ABC transporter, peptidase/ATP-binding protein; IMG reference gene:250477 [...]
       0.773
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
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