Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEE48674.1Restriction modification system DNA specificity domain protein; COGs: COG0732 Restriction endonuclease S subunits; InterPro IPR000055; KEGG: gbm:Gbem_3569 type I restriction-modification system DNA specificity subunit; PFAM: Restriction endonuclease, type I, S subunit, EcoBI; SPTR: Type I restriction-modification system DNA specificity subunit; IMG reference gene:2504770126; PFAM: Type I restriction modification DNA specificity domain. (404 aa)    
Predicted Functional Partners:
AEE48673.1
N-6 DNA methylase; COGs: COG0286 Type I restriction-modification system methyltransferase subunit; InterPro IPR003356; KEGG: afr:AFE_1577 type I restriction-modification system, M subunit; PFAM: DNA methylase, adenine-specific; SPTR: Type I restriction-modification system, M subunit; IMG reference gene:2504770125; PFAM: N-6 DNA Methylase; HsdM N-terminal domain.
 
 
 0.978
AEE48676.1
COGs: COG4096 Type I site-specific restriction-modification system R (restriction) subunit and related helicase; InterPro IPR007409:IPR006935:IPR013670:IPR014001; KEGG: ank:AnaeK_1537 type III restriction protein res subunit; PFAM: Restriction endonuclease, type I, EcoEI, R subunit/Type III, Res subunit, C-terminal; Restriction endonuclease, type I, R subunit/Type III, Res subunit; Restriction endonuclease, type I, EcoRI, R subunit/Type III, Res subunit, N-terminal; PRIAM: Type I site-specific deoxyribonuclease; SMART: DEAD-like helicase, N-terminal; SPTR: Type I restriction-modificati [...]
 
 
 0.962
AEE49371.1
N-6 DNA methylase; COGs: COG0286 Type I restriction-modification system methyltransferase subunit; InterPro IPR003356; KEGG: mtt:Ftrac_1391 N-6 DNA methylase; PFAM: DNA methylase, adenine-specific; SPTR: N-6 DNA methylase; IMG reference gene:2504770838; PFAM: N-6 DNA Methylase; HsdM N-terminal domain.
 
 
 0.906
AEE48675.1
Death-on-curing family protein; COGs: COG3943 Virulence protein; InterPro IPR003812:IPR006440; KEGG: noc:Noc_1805 death-on-curing protein; PFAM: Filamentation induced by cAMP/death on curing, related; SPTR: Virulence protein; TIGRFAM: Death-on-curing protein; IMG reference gene:2504770127; PFAM: Fic/DOC family; TIGRFAM: death-on-curing family protein.
  
    0.864
AEE49373.1
COGs: COG4096 Type I site-specific restriction-modification system R (restriction) subunit and related helicase; InterPro IPR007409:IPR006935:IPR001650:IPR014001; KEGG: nhl:Nhal_3962 type III restriction protein res subunit; PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; Restriction endonuclease, type I, EcoRI, R subunit/Type III, Res subunit, N-terminal; DNA/RNA helicase, C-terminal; PRIAM: Type I site-specific deoxyribonuclease; SMART: DEAD-like helicase, N-terminal; SPTR: Type III restriction protein res subunit; IMG reference gene:2504770840; PFAM: Type I [...]
 
 
 0.833
AEE50068.1
N-6 DNA methylase; COGs: COG0286 Type I restriction-modification system methyltransferase subunit; InterPro IPR003356; KEGG: kvu:EIO_2897 type I restriction-modification system methyltransferase subunit; PFAM: DNA methylase, adenine-specific; SPTR: Type I restriction-modification system methyltransferase subunit; IMG reference gene:2504771552; PFAM: N-6 DNA Methylase; HsdM N-terminal domain.
 
 
 0.723
AEE52722.1
N-6 DNA methylase; COGs: COG0286 Type I restriction-modification system methyltransferase subunit; InterPro IPR003356; KEGG: chu:CHU_2941 restriction/modification methyltransferase; PFAM: DNA methylase, adenine-specific; SPTR: Restriction/modification methyltransferase; IMG reference gene:2504774288; PFAM: N-6 DNA Methylase; HsdM N-terminal domain.
 
 
 0.689
AEE51087.1
N-6 DNA methylase; COGs: COG0286 Type I restriction-modification system methyltransferase subunit; InterPro IPR003356; KEGG: lby:Lbys_0413 N-6 DNA methylase; PFAM: DNA methylase, adenine-specific; SPTR: N-6 DNA methylase family protein; IMG reference gene:2504772607; PFAM: N-6 DNA Methylase.
 
 
 0.652
AEE50073.1
Hypothetical protein; KEGG: gfo:GFO_1371 type I restriction-modification system methyltransferase subunit; SPTR: Type I restriction-modification system methyltransferase subunit; IMG reference gene:2504771557; PFAM: N-6 DNA Methylase.
 
 
 0.643
AEE53379.1
KEGG: nde:NIDE3670 DNA modification methylase; SPTR: DNA modification methylase; IMG reference gene:2504774953; PFAM: Eco57I restriction endonuclease.
  
 
 0.603
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
Server load: low (6%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.