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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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AEE48739.1TIM-barrel protein, nifR3 family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (352 aa)    
Predicted Functional Partners:
AEE48738.1
Polynucleotide adenylyltransferase/metal dependent phosphohydrolase; COGs: COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; InterPro IPR002646:IPR006674; KEGG: dfe:Dfer_2415 polynucleotide adenylyltransferase/metal dependent phosphohydrolase; PFAM: Polynucleotide adenylyltransferase region; Metal-dependent phosphohydrolase, HD region, subdomain; PRIAM: tRNA adenylyltransferase; SPTR: Polynucleotide adenylyltransferase/metal dependent phosphohydrolase; IMG reference gene:2504770193; PFAM: HD domain; Poly A polymerase head domain; TIGRFAM: uncharacterized domain HDIG; Belongs to t [...]
  
  
 0.781
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 
 
 0.633
truA-2
tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
 
 
 0.564
trmB
tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
 
 
 0.546
priA
Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily.
 
     0.543
truA
tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
 
 
 0.534
AEE50901.1
RNA methyltransferase, TrmA family; COGs: COG2265 SAM-dependent methyltransferase related to tRNA (uracil-5-)-methyltransferase; InterPro IPR007848:IPR010280:IPR001566; KEGG: gfo:GFO_1887 tRNA (uracil-5-)-methyltransferase; PFAM: (Uracil-5)-methyltransferase; Methyltransferase small; SPTR: 23S rRNA (Uracil-5-)-methyltransferase RumA; TIGRFAM: 23S rRNA methyltransferase/RumA; IMG reference gene:2504772417; PFAM: tRNA (Uracil-5-)-methyltransferase; TIGRFAM: 23S rRNA (uracil-5-)-methyltransferase RumA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltr [...]
 
  
 0.513
pheT
COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; HAMAP: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; InterProIPR004532:IPR002547:IPR005146:IPR005147:IPR 005121; KEGG: phe:Phep_0825 phenylalanyl-tRNA synthetase subunit beta; PFAM: B3/B4 tRNA-binding domain; tRNA-binding region; tRNA synthetase, B5; Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding; SPTR: Phenylalanine--tRNA ligase; TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; IMG reference gene:2504772211; PFAM: tRNA synthetase B5 domain; B3/4 domain; [...]
 
  
 0.494
AEE48520.1
Alcohol dehydrogenase GroES domain protein; COGs: COG1062 Zn-dependent alcohol dehydrogenase class III; InterPro IPR013154:IPR013149; KEGG: alcohol dehydrogenase GroES domain protein; PFAM: Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, zinc-binding; SPTR: MS123, putative alcohol dehydrogenase; IMG reference gene:2504769967; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase.
    
   0.478
mfd
Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
 
     0.473
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
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