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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (395 aa)    
Predicted Functional Partners:
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
 
 0.935
AEE48754.1
L-threonine 3-dehydrogenase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: mtt:Ftrac_2956 nad-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; PRIAM: L-threonine 3-dehydrogenase; SPTR: L-threonine dehydrogenase; IMG reference gene:2504770209; PFAM: NAD dependent epimerase/dehydratase family.
 
 
 0.924
AEE50861.1
8-amino-7-oxononanoate synthase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839; KEGG: ran:Riean_0499 8-amino-7-oxononanoate synthase; PFAM: Aminotransferase, class I/II; PRIAM: 8-amino-7-oxononanoate synthase; SPTR: 2-amino-3-ketobutyrate CoA ligase (Glycine acetyltransferase); IMG reference gene:2504772372; PFAM: Aminotransferase class I and II.
  
  
 
0.923
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.913
AEE49270.1
COGs: COG2008 Threonine aldolase; InterPro IPR001597; KEGG: cre:CHLREDRAFT_141056 threonine aldolase family protein; PFAM: Aromatic amino acid beta-eliminating lyase/threonine aldolase; PRIAM: Threonine aldolase; SPTR: Threonine aldolase family protein; IMG reference gene:2504770736; PFAM: Beta-eliminating lyase.
   
 
 0.908
AEE51215.1
Alanine--glyoxylate transaminase; COGs: COG0160 4-aminobutyrate aminotransferase and related aminotransferase; InterPro IPR005814; KEGG: sus:Acid_7662 aminotransferase; PFAM: Aminotransferase class-III; PRIAM: Alanine--glyoxylate transaminase; SPTR: Aminotransferase; IMG reference gene:2504772737; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
   
 0.906
AEE49946.1
Sarcosine oxidase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: hvo:HVO_B0011 sarcosine oxidase; PFAM: FAD dependent oxidoreductase; PRIAM: Sarcosine oxidase; SPTR: Monomeric sarcosine oxidase; IMG reference gene:2504771428; PFAM: FAD dependent oxidoreductase; TIGRFAM: sarcosine oxidase, monomeric form.
  
 
 0.904
bioD
Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
  
 0.759
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
  
 0.653
AEE53062.1
COGs: COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; InterPro IPR005815:IPR005814; KEGG: sli:Slin_5888 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: Aminotransferase class-III; PRIAM: Adenosylmethionine--8-amino-7-oxononanoate transaminase; SPTR: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; TIGRFAM: Adenosylmethionine--8-amino-7-oxononanoate aminotransferase; IMG reference gene:2504774634; PFAM: Aminotransferase class-III; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate transaminase; Belongs to the class-III pyridoxal-phosphate [...]
 
  
 0.629
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
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