Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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AEE48784.1Serine dehydratase alpha chain; COGs: COG1760 L-serine deaminase; InterPro IPR005131:IPR005130; KEGG: rba:RB8979 L-serine dehydratase, alpha chain; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; SPTR: Probable L-serine dehydratase, alpha chain; IMG reference gene:2504770240; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; L-serine dehydratase, iron-sulfur-dependent, alpha subunit. (526 aa)    
Predicted Functional Partners:
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.944
AEE51799.1
COGs: COG1760 L-serine deaminase; InterPro IPR004644:IPR005131:IPR005130; KEGG: fps:FP0884 L-serine ammonia-lyase; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; SPTR: L-serine ammonia-lyase; TIGRFAM: Iron-sulphur-dependent L-serine dehydratase single chain form; IMG reference gene:2504773336; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; L-serine dehydratase, iron-sulfur-dependent, single chain form.
  
  
 
0.928
AEE54139.1
COGs: COG0031 Cysteine synthase; InterPro IPR001926:IPR000644; KEGG: phe:Phep_1434 cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Cystathionine beta-synthase, core; PRIAM: Cysteine synthase; SMART: Cystathionine beta-synthase, core; SPTR: Cystathionine beta-synthase; IMG reference gene:2504775728; PFAM: CBS domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase.
  
 
 0.914
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
   
 
 0.911
AEE49498.1
COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cystathionine beta-synthase; IMG reference gene:2504770968; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cystathionine beta-synthase.
  
 
 0.910
AEE50297.1
COGs: COG1045 Serine acetyltransferase; InterPro IPR001451; KEGG: chu:CHU_0685 serine O-acetyltransferase; PRIAM: Serine O-acetyltransferase; SPTR: Serine O-acetyltransferase; IMG reference gene:2504771792; PFAM: Bacterial transferase hexapeptide (three repeats); TIGRFAM: serine O-acetyltransferase.
     
 0.908
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.900
AEE50811.1
CDP-alcohol phosphatidyltransferase; COGs: COG1183 Phosphatidylserine synthase; InterPro IPR000462; KEGG: mtt:Ftrac_1738 cdp-alcohol phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; SPTR: CDP-diacylglycerol--serine O-phosphatidyltransferase; IMG reference gene:2504772321; PFAM: CDP-alcohol phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
     
  0.900
trpB-2
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
 0.900
AEE50854.1
COGs: COG0527 Aspartokinase; InterProIPR001048:IPR002912:IPR005106:IPR001342:IPR 001341; KEGG: chu:CHU_0073 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Aspartate/homoserine dehydrogenase, NAD-binding; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: Bifunctional protein: aspartokinase I; homoserine dehydrogenase; TIGRFAM: Aspartate kinase region; IMG reference gene:2504772364; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT dom [...]
  
 
 0.833
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
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