Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEE48876.1Histidine kinase; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterPro IPR003594:IPR003661; KEGG: sli:Slin_3715 histidine kinase; PFAM: ATP-binding region, ATPase-like; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SPTR: Sensor histidine kinase; IMG reference gene:2504770337; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (686 aa)    
Predicted Functional Partners:
AEE53439.1
COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001789:IPR001054; KEGG: dfe:Dfer_1110 adenylate/guanylate cyclase; PFAM: Adenylyl cyclase class-3/4/guanylyl cyclase; Signal transduction response regulator, receiver region; SMART: Signal transduction response regulator, receiver region; Adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: Adenylate/guanylate cyclase; IMG reference gene:2504775013; PFAM: Adenylate and Guanylate cyclase catalytic domain; Response regulator receiver domain.
 
 
 
 0.806
AEE53440.1
COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789; KEGG: dfe:Dfer_1111 response regulator receiver protein; PFAM: Signal transduction response regulator, receiver region; SMART: Signal transduction response regulator, receiver region; SPTR: Response regulator receiver protein; IMG reference gene:2504775014; PFAM: Response regulator receiver domain.
 
 
   0.798
AEE48877.1
COGs: COG1629 Outer membrane receptor protein mostly Fe transport; InterPro IPR012910:IPR000531; KEGG: nar:Saro_0866 TonB-dependent receptor; PFAM: TonB-dependent receptor, beta-barrel; TonB-dependent receptor, plug; SPTR: TonB-dependent receptor; IMG reference gene:2504770338; PFAM: TonB-dependent Receptor Plug Domain; TonB dependent receptor.
       0.773
AEE53006.1
Sigma54 specific transcriptional regulator with PAS/PAC sensor, Fis family; COGs: COG3604 Transcriptional regulator containing GAF AAA-type ATPase and DNA binding domains; InterProIPR013767:IPR002078:IPR002197:IPR000014:IPR 003593; KEGG: gme:Gmet_2109 Fis family transcriptional regulator; PFAM: RNA polymerase sigma factor 54, interaction; PAS fold; Helix-turn-helix, Fis-type; SMART: ATPase, AAA+ type, core; PAS; SPTR: Transcriptional regulator, Fis family / DNA-binding protein Fis; TIGRFAM: PAS; IMG reference gene:2504774578; PFAM: Bacterial regulatory protein, Fis family; Sigma-54 int [...]
 
 
 
 0.688
AEE52899.1
Signal transduction histidine kinase with CheB and CheR activity; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
 
 
0.681
AEE48572.1
Adenylate/guanylate cyclase with TPR repeats; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterProIPR003018:IPR013656:IPR001054:IPR013105:IPR 000014; KEGG: dsa:Desal_0985 adenylate/guanylate cyclase with GAF and PAS/PAC sensors; PFAM: Adenylyl cyclase class-3/4/guanylyl cyclase; GAF; PAS fold-4; Tetratricopeptide TPR2; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase; GAF; PAS; SPTR: Adenylate/guanylate cyclase with GAF and PAS/PAC sensors; TIGRFAM: PAS; IMG reference gene:2504770022; PFAM: Adenylate and Guanylate cyclase catalytic domain; GAF domain; [...]
 
 
 
 0.650
AEE53486.1
PAS/PAC sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR003661:IPR003594:IPR001789:IPR 013656:IPR013767; KEGG: ppn:Palpr_2639 pas/pac sensor hybrid histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; PAS fold-4; PAS fold; Signal transduction response regulator, receiver region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; PAS; Signal transduction response reg [...]
 
 
0.632
AEE48874.1
ATP-binding region ATPase domain protein; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR001440:IPR013105:IPR003661:IPR003594:IPR 019734; KEGG: sli:Slin_3715 histidine kinase; PFAM: ATP-binding region, ATPase-like; Tetratricopeptide TPR2; Tetratricopeptide TPR-1; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; Tetratricopeptide repeat; SPTR: Sensor histidine kina [...]
 
    
0.580
AEE49322.1
Integral membrane sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003661:IPR003594:IPR001789; KEGG: cyn:Cyan7425_3279 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; Signal transduction response regulator, receiver region; SMART: Signal transduction response regulator, receiver region; ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SPTR: Multi-sensor hy [...]
 
 
 0.541
AEE48878.1
InterPro IPR002559; KEGG: npu:Npun_BR171 transposase, IS4 family protein; PFAM: Transposase, IS4-like; SPTR: Transposase, IS4 family protein; IMG reference gene:2504770339; PFAM: Transposase DDE domain.
 
     0.534
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.