Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
tsaDO-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (333 aa)    
Predicted Functional Partners:
AEE49876.1
Universal protein YeaZ; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: phe:Phep_1546 peptidase M22 glycoprotease; PFAM: Peptidase M22, glycoprotease; SPTR: Universal bacterial protein YeaZ; TIGRFAM: universal protein YeaZ; IMG reference gene:2504771357; PFAM: Glycoprotease family; TIGRFAM: universal bacterial protein YeaZ.
 
 
 0.934
AEE50606.1
Uncharacterized protein family UPF0079, ATPase; COGs: COG0802 ATPase or kinase; InterPro IPR003442; KEGG: hypothetical protein; PFAM: Uncharacterised protein family UPF0079, ATPase bacteria; SPTR: Putative uncharacterized protein; TIGRFAM: Uncharacterised protein family UPF0079, ATPase bacteria; IMG reference gene:2504772109; PFAM: Uncharacterised P-loop hydrolase UPF0079; TIGRFAM: ATPase, YjeE family.
 
 
 0.909
rsmA
Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
 
  
 0.792
pheS
COGs: COG0016 Phenylalanyl-tRNA synthetase alpha subunit; HAMAP: Phenylalanyl-tRNA synthetase alpha chain; InterPro IPR004188:IPR002319:IPR004529; KEGG: cpi:Cpin_0692 phenylalanyl-tRNA synthetase, alpha subunit; PFAM: Phenylalanyl-tRNA synthetase alpha chain; Phenylalanyl-tRNA synthetase, class II, N-terminal; SPTR: Phenylalanyl-tRNA synthetase alpha chain; TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, alpha subunit; IMG reference gene:2504771402; PFAM: tRNA synthetases class II core domain (F); Aminoacyl tRNA synthetase class II, N-terminal domain; TIGRFAM: phenylalanyl-tRNA synth [...]
 
   
 0.730
AEE51863.1
COGs: COG0172 Seryl-tRNA synthetase; InterPro IPR015866:IPR002314:IPR002317; KEGG: coc:Coch_0734 seryl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved region; Seryl-tRNA synthetase, class IIa, N-terminal; PRIAM: Serine--tRNA ligase; SPTR: Serine--tRNA ligase; TIGRFAM: Seryl-tRNA synthetase, class IIa; IMG reference gene:2504773400; PFAM: Seryl-tRNA synthetase N-terminal domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: seryl-tRNA synthetase.
 
  
 0.715
AEE48104.1
Sua5/YciO/YrdC/YwlC family protein; COGs: COG0009 Putative translation factor (SUA5); InterPro IPR006070:IPR004388; KEGG: mtt:Ftrac_1708 translation factor SUA5; PFAM: Sua5/YciO/YrdC, N-terminal; SPTR: Translation factor SUA5; TIGRFAM: Sua5/YciO/YrdC/YwlC; IMG reference gene:2504769543; PFAM: yrdC domain; TIGRFAM: Sua5/YciO/YrdC/YwlC family protein; Belongs to the SUA5 family.
 
 0.698
lolD
Fe(3+)-transporting ATPase; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
 
    0.690
rpsE
Ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family.
  
   
 0.653
AEE51514.1
Phosphonate-transporting ATPase; COGs: COG1136 ABC-type antimicrobial peptide transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: lby:Lbys_3320 ABC transporter related protein; PFAM: ABC transporter-like; PRIAM: Phosphonate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein; IMG reference gene:2504773043; PFAM: ABC transporter.
 
    0.651
AEE51614.1
Phosphonate-transporting ATPase; COGs: COG1136 ABC-type antimicrobial peptide transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: rrs:RoseRS_3212 cyclic nucleotide-binding protein; PFAM: ABC transporter-like; PRIAM: Phosphonate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Cyclic nucleotide-binding protein; IMG reference gene:2504773143; PFAM: ABC transporter.
 
    0.629
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
Server load: low (12%) [HD]