STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (355 aa)    
Predicted Functional Partners:
AEE54102.1
Three-deoxy-D-manno-octulosonic-acid transferase domain-containing protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
 0.991
AEE52890.1
lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
  
 0.983
AEE48932.1
Glycosyl transferase family 39; COGs: COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferase of PMT family; InterPro IPR003342; KEGG: pfo:Pfl01_2835 4-amino-4-deoxy-L-arabinose transferase; PFAM: Glycosyl transferase, family 39; SPTR: PMT family glycosyltransferase, 4-amino-4-deoxy-L-arabinose transferase; IMG reference gene:2504770394; PFAM: Dolichyl-phosphate-mannose-protein mannosyltransferase.
  
  
 0.915
AEE50640.1
KpsF/GutQ family protein; COGs: COG0794 sugar phosphate isomerase involved in capsule formation; InterPro IPR000644:IPR001347:IPR004800; KEGG: cat:CA2559_12348 sugar isomerase, KpsF/GutQ family protein; PFAM: Sugar isomerase (SIS); Cystathionine beta-synthase, core; PRIAM: Arabinose-5-phosphate isomerase; SPTR: Sugar phosphate isomerase, KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ; IMG reference gene:2504772143; PFAM: CBS domain; SIS domain; TIGRFAM: KpsF/GutQ family protein; Belongs to the SIS family. GutQ/KpsF subfamily.
 
   
 0.849
kdsB
3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
 
   
 0.837
AEE52542.1
acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
   
 0.835
AEE52368.1
2-dehydro-3-deoxyphosphooctonate aldolase; COGs: COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; InterPro IPR006218:IPR006269; KEGG: phe:Phep_2065 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-8-phosphooctulonate synthase; SPTR: 3-deoxy-8-phosphooctulonate synthase; TIGRFAM: 3-deoxy-8-phosphooctulonate synthase; IMG reference gene:2504773915; PFAM: DAHP synthetase I family; TIGRFAM: 3-deoxy-8-phosphooctulonate synthase.
 
   
 0.828
lpxD
UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
 
   
 0.819
AEE51147.1
COGs: COG1560 Lauroyl/myristoyl acyltransferase; InterPro IPR004960; KEGG: cpi:Cpin_2595 lipid A biosynthesis acyltransferase; PFAM: Bacterial lipid A biosynthesis acyltransferase; SPTR: Lipid A biosynthesis acyltransferase; IMG reference gene:2504772668; PFAM: Bacterial lipid A biosynthesis acyltransferase.
 
  
 0.806
AEE50949.1
UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase, non-repeat region; COGs: COG1044 UDP-3-O-(3-hydroxymyristoyl); InterPro IPR020573:IPR001451; KEGG: coc:Coch_1759 UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; PFAM: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, non-repeat region; Bacterial transferase hexapeptide repeat; SPTR: UDP-3-O-3-hydroxymyristoyl glucosamine N-acyltransferase; IMG reference gene:2504772466; PFAM: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Bacterial transferase hexapeptide (three repeats); TIGRFAM: UDP-3 [...]
 
   
 0.804
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
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