| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEE48355.1 | AEE49900.1 | Halhy_0444 | Halhy_2015 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709; KEGG: bth:BT_1858 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase; IMG reference gene:2504771381; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.862 |
| AEE48355.1 | AEE50856.1 | Halhy_0444 | Halhy_2992 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | COGs: COG0498 Threonine synthase; InterPro IPR001926:IPR004450; KEGG: dfe:Dfer_3806 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Threonine synthase; SPTR: Threonine synthase; TIGRFAM: Threonine synthase; IMG reference gene:2504772366; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. | 0.422 |
| AEE48355.1 | AEE53775.1 | Halhy_0444 | Halhy_5952 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | 2-isopropylmalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891; KEGG: fbc:FB2170_13141 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; PRIAM: 2-isopropylmalate synthase; SPTR: 2-isopropylmalate synthase; IMG reference gene:2504775352; PFAM: HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.862 |
| AEE48355.1 | AEE53783.1 | Halhy_0444 | Halhy_5960 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | COGs: COG0059 Ketol-acid reductoisomerase; InterPro IPR013023:IPR013116:IPR000506; KEGG: cpi:Cpin_1923 ketol-acid reductoisomerase; PFAM: Acetohydroxy acid isomeroreductase, catalytic; Acetohydroxy acid isomeroreductase C-terminal; PRIAM: Ketol-acid reductoisomerase; SPTR: Ketol-acid reductoisomerase; TIGRFAM: Acetohydroxy acid isomeroreductase; IMG reference gene:2504775360; PFAM: Acetohydroxy acid isomeroreductase, catalytic domain; TIGRFAM: ketol-acid reductoisomerase. | 0.430 |
| AEE48355.1 | AEE54340.1 | Halhy_0444 | Halhy_6524 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR004789:IPR002912:IPR019455; KEGG: fps:FP0447 acetolactate synthase small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT; SPTR: Acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; IMG reference gene:2504775933; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. | 0.875 |
| AEE48355.1 | AEE54341.1 | Halhy_0444 | Halhy_6525 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | Acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012846:IPR012001:IPR012000:IPR011766; KEGG: phe:Phep_3419 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Acetolactate synthase; SPTR: Acetolactate synthase large subunit; TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; IMG reference gene:2504775934; PFAM: Thiamine py [...] | 0.927 |
| AEE48355.1 | leuB | Halhy_0444 | Halhy_2016 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.434 |
| AEE48355.1 | leuB-2 | Halhy_0444 | Halhy_5951 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.434 |
| AEE48355.1 | leuC | Halhy_0444 | Halhy_2013 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.829 |
| AEE48355.1 | leuD | Halhy_0444 | Halhy_2014 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.835 |
| AEE49900.1 | AEE48355.1 | Halhy_2015 | Halhy_0444 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709; KEGG: bth:BT_1858 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase; IMG reference gene:2504771381; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | 0.862 |
| AEE49900.1 | AEE53775.1 | Halhy_2015 | Halhy_5952 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709; KEGG: bth:BT_1858 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase; IMG reference gene:2504771381; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891; KEGG: fbc:FB2170_13141 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; PRIAM: 2-isopropylmalate synthase; SPTR: 2-isopropylmalate synthase; IMG reference gene:2504775352; PFAM: HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.908 |
| AEE49900.1 | AEE53783.1 | Halhy_2015 | Halhy_5960 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709; KEGG: bth:BT_1858 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase; IMG reference gene:2504771381; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. | COGs: COG0059 Ketol-acid reductoisomerase; InterPro IPR013023:IPR013116:IPR000506; KEGG: cpi:Cpin_1923 ketol-acid reductoisomerase; PFAM: Acetohydroxy acid isomeroreductase, catalytic; Acetohydroxy acid isomeroreductase C-terminal; PRIAM: Ketol-acid reductoisomerase; SPTR: Ketol-acid reductoisomerase; TIGRFAM: Acetohydroxy acid isomeroreductase; IMG reference gene:2504775360; PFAM: Acetohydroxy acid isomeroreductase, catalytic domain; TIGRFAM: ketol-acid reductoisomerase. | 0.626 |
| AEE49900.1 | AEE54340.1 | Halhy_2015 | Halhy_6524 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709; KEGG: bth:BT_1858 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase; IMG reference gene:2504771381; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR004789:IPR002912:IPR019455; KEGG: fps:FP0447 acetolactate synthase small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT; SPTR: Acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; IMG reference gene:2504775933; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. | 0.975 |
| AEE49900.1 | AEE54341.1 | Halhy_2015 | Halhy_6525 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709; KEGG: bth:BT_1858 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase; IMG reference gene:2504771381; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012846:IPR012001:IPR012000:IPR011766; KEGG: phe:Phep_3419 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Acetolactate synthase; SPTR: Acetolactate synthase large subunit; TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; IMG reference gene:2504775934; PFAM: Thiamine py [...] | 0.969 |
| AEE49900.1 | leuB | Halhy_2015 | Halhy_2016 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709; KEGG: bth:BT_1858 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase; IMG reference gene:2504771381; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.914 |
| AEE49900.1 | leuB-2 | Halhy_2015 | Halhy_5951 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709; KEGG: bth:BT_1858 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase; IMG reference gene:2504771381; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.790 |
| AEE49900.1 | leuC | Halhy_2015 | Halhy_2013 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709; KEGG: bth:BT_1858 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase; IMG reference gene:2504771381; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.989 |
| AEE49900.1 | leuD | Halhy_2015 | Halhy_2014 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709; KEGG: bth:BT_1858 2-isopropylmalate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase; IMG reference gene:2504771381; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.993 |
| AEE50856.1 | AEE48355.1 | Halhy_2992 | Halhy_0444 | COGs: COG0498 Threonine synthase; InterPro IPR001926:IPR004450; KEGG: dfe:Dfer_3806 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Threonine synthase; SPTR: Threonine synthase; TIGRFAM: Threonine synthase; IMG reference gene:2504772366; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | 0.422 |