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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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uvrCUvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (602 aa)    
Predicted Functional Partners:
uvrB
UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...]
 
 0.981
AEE52338.1
Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
 
 0.876
AEE50458.1
Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
 
 0.875
AEE51555.1
ABC transporter related protein; COGs: COG0178 Excinuclease ATPase subunit; InterPro IPR003593:IPR003439; KEGG: rci:RCIX2175 putative excinuclease ABC, ATPase subunit; PFAM: ABC transporter-like; SPTR: Putative excinuclease ABC, ATPase subunit; IMG reference gene:2504773084; PFAM: ABC transporter; TIGRFAM: excinuclease ABC, A subunit.
 
 
 0.793
AEE50022.1
InterPro IPR006619:IPR002502; KEGG: mtt:Ftrac_1437 N-acetylmuramoyl-L-alanine amidase family 2; PFAM: N-acetylmuramoyl-L-alanine amidase, family 2; SMART: Peptidoglycan recognition protein, metazoa/bacteria; N-acetylmuramoyl-L-alanine amidase, family 2; SPTR: N-acetylmuramoyl-L-alanine amidase family 2; IMG reference gene:2504771504; PFAM: N-acetylmuramoyl-L-alanine amidase.
       0.773
ruvB
Holliday junction ATP-dependent DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
 
 
 0.714
ruvA
Holliday junction ATP-dependent DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
  
  
 0.678
AEE50023.1
TrkA-N domain protein; COGs: COG0569 K+ transport systems NAD-binding component; InterPro IPR013099:IPR003148; KEGG: fbc:FB2170_16251 potassium channel; PFAM: Regulator of K+ conductance, N-terminal; Ion transport 2; SPTR: Potassium uptake protein, TrkA family; IMG reference gene:2504771505; PFAM: Ion channel; TrkA-N domain; TrkA-C domain.
     
 0.668
AEE50556.1
UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: chu:CHU_3266 DNA-dependent ATPase I and helicase II; PFAM: DNA helicase, UvrD/REP type; SPTR: DNA-dependent ATPase I and helicase II; IMG reference gene:2504772059; PFAM: UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily.
  
  
 0.668
AEE49750.1
UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: chu:CHU_1554 ATP-dependent DNA helicase II; PFAM: DNA helicase, UvrD/REP type; SPTR: ATP-dependent DNA helicase II; IMG reference gene:2504771226; PFAM: UvrD/REP helicase.
 
  
 0.652
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
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