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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
uvrCUvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (602 aa)    
Predicted Functional Partners:
uvrB
UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...]
 0.981
AEE52338.1
Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
 
 0.879
AEE50458.1
Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
 
 0.878
AEE51555.1
ABC transporter related protein; COGs: COG0178 Excinuclease ATPase subunit; InterPro IPR003593:IPR003439; KEGG: rci:RCIX2175 putative excinuclease ABC, ATPase subunit; PFAM: ABC transporter-like; SPTR: Putative excinuclease ABC, ATPase subunit; IMG reference gene:2504773084; PFAM: ABC transporter; TIGRFAM: excinuclease ABC, A subunit.
 
 
 0.797
AEE50022.1
InterPro IPR006619:IPR002502; KEGG: mtt:Ftrac_1437 N-acetylmuramoyl-L-alanine amidase family 2; PFAM: N-acetylmuramoyl-L-alanine amidase, family 2; SMART: Peptidoglycan recognition protein, metazoa/bacteria; N-acetylmuramoyl-L-alanine amidase, family 2; SPTR: N-acetylmuramoyl-L-alanine amidase family 2; IMG reference gene:2504771504; PFAM: N-acetylmuramoyl-L-alanine amidase.
       0.773
mutL
DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
 
 
 0.682
AEE50556.1
UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: chu:CHU_3266 DNA-dependent ATPase I and helicase II; PFAM: DNA helicase, UvrD/REP type; SPTR: DNA-dependent ATPase I and helicase II; IMG reference gene:2504772059; PFAM: UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily.
  
  
 0.676
AEE50023.1
TrkA-N domain protein; COGs: COG0569 K+ transport systems NAD-binding component; InterPro IPR013099:IPR003148; KEGG: fbc:FB2170_16251 potassium channel; PFAM: Regulator of K+ conductance, N-terminal; Ion transport 2; SPTR: Potassium uptake protein, TrkA family; IMG reference gene:2504771505; PFAM: Ion channel; TrkA-N domain; TrkA-C domain.
     
 0.672
AEE49750.1
UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: chu:CHU_1554 ATP-dependent DNA helicase II; PFAM: DNA helicase, UvrD/REP type; SPTR: ATP-dependent DNA helicase II; IMG reference gene:2504771226; PFAM: UvrD/REP helicase.
 
  
 0.659
ruvB
Holliday junction ATP-dependent DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
 
  
 0.575
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
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