Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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AEE50081.1DNA-(apurinic or apyrimidinic site) lyase; COGs: COG0266 Formamidopyrimidine-DNA glycosylase; InterPro IPR012319:IPR015886; KEGG: zpr:ZPR_0123 formamidopyrimidine-DNA glycosylase; PFAM: DNA glycosylase/AP lyase, catalytic domain; DNA glycosylase/AP lyase, H2TH DNA-binding; PRIAM: DNA-(apurinic or apyrimidinic site) lyase; SPTR: Formamidopyrimidine-DNA glycosylase; IMG reference gene:2504771566; PFAM: Formamidopyrimidine-DNA glycosylase H2TH domain; Formamidopyrimidine-DNA glycosylase N-terminal domain; TIGRFAM: formamidopyrimidine-DNA glycosylase (fpg). (258 aa)    
Predicted Functional Partners:
AEE53940.1
COGs: COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonuclease; InterPro IPR006054:IPR013520:IPR000305:IPR006055; KEGG: gfo:GFO_0663 exonuclease family protein; PFAM: Exonuclease, RNase T/DNA polymerase III; Excinuclease ABC, C subunit, N-terminal; PRIAM: DNA-directed DNA polymerase; SMART: Exonuclease; Excinuclease ABC, C subunit, N-terminal; SPTR: DNA polymerase III, epsilon subunit; TIGRFAM: DNA polymerase III, epsilon subunit; IMG reference gene:2504775520; PFAM: Exonuclease; GIY-YIG catalytic domain; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family.
  
  
 0.803
coaE
Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
  
  
 0.729
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.702
AEE50082.1
Glycogen debranching enzyme GlgX; COGs: COG1523 Type II secretory pathway pullulanase PulA and related glycosidase; InterPro IPR011837:IPR006589:IPR004193:IPR006047; KEGG: cts:Ctha_2659 glycogen debranching enzyme GlgX; PFAM: Glycoside hydrolase, family 13, N-terminal; Glycosyl hydrolase, family 13, catalytic region; PRIAM: Isoamylase; SMART: Glycosyl hydrolase, family 13, subfamily, catalytic region; SPTR: Glycogen debranching enzyme GlgX; TIGRFAM: Glycogen debranching enzyme GlgX; IMG reference gene:2504771567; PFAM: Alpha amylase, catalytic domain; Carbohydrate-binding module 48 (Is [...]
       0.549
uvrC
UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
  
  
 0.544
AEE50080.1
Peptidase S9 prolyl oligopeptidase active site domain protein; COGs: COG1506 Dipeptidyl aminopeptidase/acylaminoacyl-peptidase; InterPro IPR001375; KEGG: sli:Slin_0636 peptidase S9 prolyl oligopeptidase active site domain protein; SPTR: Putative secreted protein; IMG reference gene:2504771565; PFAM: Prolyl oligopeptidase family.
       0.477
ruvA
Holliday junction ATP-dependent DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
 
   
 0.420
AEE53221.1
PHP domain protein; COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR004013:IPR002054:IPR003583:IPR003141; KEGG: cpi:Cpin_2044 PHP domain protein; PFAM: PHP, C-terminal; SMART: Polymerase/histidinol phosphatase, N-terminal; DNA-directed DNA polymerase, family X; Helix-hairpin-helix DNA-binding motif, class 1; SPTR: PHP domain protein; IMG reference gene:2504774794; PFAM: PHP domain; Bacterial RNA polymerase, alpha chain C terminal domain.
     
 0.416
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
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