Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEE50158.1COGs: COG3836 2 4-dihydroxyhept-2-ene-1 7-dioic acid aldolase; InterPro IPR005000; KEGG: sli:Slin_1071 4-hydroxy-2-oxovalerate aldolase; PFAM: HpcH/HpaI aldolase; PRIAM: 2-dehydro-3-deoxyglucarate aldolase; SPTR: 4-hydroxy-2-oxovalerate aldolase; IMG reference gene:2504771647; PFAM: HpcH/HpaI aldolase/citrate lyase family; Belongs to the HpcH/HpaI aldolase family. (256 aa)    
Predicted Functional Partners:
AEE53436.1
COGs: COG3836 2 4-dihydroxyhept-2-ene-1 7-dioic acid aldolase; InterPro IPR005000; KEGG: bbr:BB0740 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; PFAM: HpcH/HpaI aldolase; PRIAM: 4-hydroxy-2-oxovalerate aldolase; SPTR: 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; IMG reference gene:2504775010; PFAM: HpcH/HpaI aldolase/citrate lyase family; Belongs to the HpcH/HpaI aldolase family.
  
  
 
0.918
AEE49483.1
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590; KEGG: tra:Trad_0120 aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase; PRIAM: Succinate-semialdehyde dehydrogenase; SPTR: Aldehyde Dehydrogenase; IMG reference gene:2504770953; PFAM: Aldehyde dehydrogenase family; TIGRFAM: succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
  
 
 0.908
AEE53010.1
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590; KEGG: thx:Thet_1020 aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase; PRIAM: Betaine-aldehyde dehydrogenase; SPTR: Aldehyde Dehydrogenase; IMG reference gene:2504774582; PFAM: Aldehyde dehydrogenase family.
  
 
 0.908
AEE50156.1
2-hydroxy-3-oxopropionate reductase; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115; KEGG: dfe:Dfer_1409 2-hydroxy-3-oxopropionate reductase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding; PRIAM: 2-hydroxy-3-oxopropionate reductase; SPTR: 2-hydroxy-3-oxopropionate reductase; IMG reference gene:2504771645; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase; TIGRFAM: 2-hydroxy-3-oxopropionate reductase.
 
 
 0.854
AEE50155.1
Glucarate dehydratase; COGs: COG4948 L-alanine-DL-glutamate epimerase; InterPro IPR013341:IPR013342; KEGG: sli:Slin_1068 mandelate racemase/muconate lactonizing protein; PFAM: Mandelate racemase/muconate lactonizing enzyme, C-terminal; Mandelate racemase/muconate lactonizing enzyme, N-terminal; PRIAM: Glucarate dehydratase; SPTR: Mandelate racemase/muconate lactonizing protein; IMG reference gene:2504771644; PFAM: Mandelate racemase / muconate lactonizing enzyme, C-terminal domain; Mandelate racemase / muconate lactonizing enzyme, N-terminal domain.
 
 
 0.844
AEE50157.1
COGs: COG2610 H+/gluconate symporter and related permease; InterPro IPR003474; KEGG: sli:Slin_1070 gluconate transporter; PFAM: Gluconate transporter; SPTR: Gluconate transporter; IMG reference gene:2504771646; PFAM: GntP family permease; TIGRFAM: gluconate transporter.
 
     0.721
AEE50159.1
InterPro IPR013428:IPR013427; KEGG: dfe:Dfer_3707 membrane-bound dehydrogenase domain protein; SPTR: Membrane-bound dehydrogenase domain protein; TIGRFAM: Putative membrane-bound dehydrogenase; Putative haem-binding region; IMG reference gene:2504771648; PFAM: Cytochrome c; TIGRFAM: putative membrane-bound dehydrogenase domain; putative heme-binding domain, Pirellula/Verrucomicrobium type.
 
     0.541
AEE50160.1
Xylose isomerase domain-containing protein TIM barrel; COGs: COG1082 Sugar phosphate isomerase/epimerase; InterPro IPR012307; KEGG: dfe:Dfer_3708 xylose isomerase domain protein TIM barrel; PFAM: Xylose isomerase, TIM barrel domain; SPTR: Xylose isomerase domain protein TIM barrel; IMG reference gene:2504771649; PFAM: Xylose isomerase-like TIM barrel.
 
     0.479
AEE49146.1
COGs: COG3384 conserved hypothetical protein; InterPro IPR004183; KEGG: cpi:Cpin_4445 extradiol ring-cleavage dioxygenase class III protein subunit B; PFAM: Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B; SPTR: Extradiol ring-cleavage dioxygenase class III protein subunit B; IMG reference gene:2504770612; PFAM: Catalytic LigB subunit of aromatic ring-opening dioxygenase.
  
  
 0.407
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
Server load: low (10%) [HD]