| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEE47968.1 | murI | Halhy_0054 | Halhy_3181 | Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.920 |
| AEE48314.1 | AEE49079.1 | Halhy_0403 | Halhy_1182 | COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: sli:Slin_5139 glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic region; SPTR: Glutamate--ammonia ligase; IMG reference gene:2504769758; PFAM: Glutamine synthetase, catalytic domain. | Glutamate synthase, NADH/NADPH, small subunit; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR006005; KEGG: cpi:Cpin_0731 glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PRIAM: Glutamate synthase (NADH); SPTR: Glutamate synthase, NADH/NADPH, small subunit; TIGRFAM: Glutamate synthase, NADH/NADPH, small subunit 1; IMG reference gene:2504770543; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthases, NADH/NADPH, small subunit. | 0.913 |
| AEE48314.1 | AEE49080.1 | Halhy_0403 | Halhy_1183 | COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: sli:Slin_5139 glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic region; SPTR: Glutamate--ammonia ligase; IMG reference gene:2504769758; PFAM: Glutamine synthetase, catalytic domain. | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: chu:CHU_3776 glutamate synthase (NADH) large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (NADH) large subunit; IMG reference gene:2504770544; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | 0.958 |
| AEE48314.1 | AEE52681.1 | Halhy_0403 | Halhy_4849 | COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: sli:Slin_5139 glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic region; SPTR: Glutamate--ammonia ligase; IMG reference gene:2504769758; PFAM: Glutamine synthetase, catalytic domain. | Glutamate--ammonia ligase; COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146; KEGG: sli:Slin_2432 glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic region; Glutamine synthetase, beta-Grasp; PRIAM: Glutamate--ammonia ligase; SPTR: Glutamate--ammonia ligase; IMG reference gene:2504774244; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain. | 0.914 |
| AEE48314.1 | AEE54120.1 | Halhy_0403 | Halhy_6301 | COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: sli:Slin_5139 glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic region; SPTR: Glutamate--ammonia ligase; IMG reference gene:2504769758; PFAM: Glutamine synthetase, catalytic domain. | COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006097:IPR006096; KEGG: rmr:Rmar_2129 Glu/Leu/Phe/Val dehydrogenase; PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region; Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; PRIAM: Glutamate dehydrogenase (NAD(P)(+)); SPTR: Glu/Leu/Phe/Val dehydrogenase; IMG reference gene:2504775708; PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.918 |
| AEE48314.1 | murI | Halhy_0403 | Halhy_3181 | COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: sli:Slin_5139 glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic region; SPTR: Glutamate--ammonia ligase; IMG reference gene:2504769758; PFAM: Glutamine synthetase, catalytic domain. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.839 |
| AEE48314.1 | purQ | Halhy_0403 | Halhy_4319 | COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: sli:Slin_5139 glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic region; SPTR: Glutamate--ammonia ligase; IMG reference gene:2504769758; PFAM: Glutamine synthetase, catalytic domain. | Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.908 |
| AEE49079.1 | AEE48314.1 | Halhy_1182 | Halhy_0403 | Glutamate synthase, NADH/NADPH, small subunit; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR006005; KEGG: cpi:Cpin_0731 glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PRIAM: Glutamate synthase (NADH); SPTR: Glutamate synthase, NADH/NADPH, small subunit; TIGRFAM: Glutamate synthase, NADH/NADPH, small subunit 1; IMG reference gene:2504770543; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthases, NADH/NADPH, small subunit. | COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: sli:Slin_5139 glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic region; SPTR: Glutamate--ammonia ligase; IMG reference gene:2504769758; PFAM: Glutamine synthetase, catalytic domain. | 0.913 |
| AEE49079.1 | AEE49080.1 | Halhy_1182 | Halhy_1183 | Glutamate synthase, NADH/NADPH, small subunit; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR006005; KEGG: cpi:Cpin_0731 glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PRIAM: Glutamate synthase (NADH); SPTR: Glutamate synthase, NADH/NADPH, small subunit; TIGRFAM: Glutamate synthase, NADH/NADPH, small subunit 1; IMG reference gene:2504770543; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthases, NADH/NADPH, small subunit. | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: chu:CHU_3776 glutamate synthase (NADH) large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (NADH) large subunit; IMG reference gene:2504770544; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | 0.999 |
| AEE49079.1 | AEE52681.1 | Halhy_1182 | Halhy_4849 | Glutamate synthase, NADH/NADPH, small subunit; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR006005; KEGG: cpi:Cpin_0731 glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PRIAM: Glutamate synthase (NADH); SPTR: Glutamate synthase, NADH/NADPH, small subunit; TIGRFAM: Glutamate synthase, NADH/NADPH, small subunit 1; IMG reference gene:2504770543; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthases, NADH/NADPH, small subunit. | Glutamate--ammonia ligase; COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146; KEGG: sli:Slin_2432 glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic region; Glutamine synthetase, beta-Grasp; PRIAM: Glutamate--ammonia ligase; SPTR: Glutamate--ammonia ligase; IMG reference gene:2504774244; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain. | 0.913 |
| AEE49079.1 | AEE54120.1 | Halhy_1182 | Halhy_6301 | Glutamate synthase, NADH/NADPH, small subunit; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR006005; KEGG: cpi:Cpin_0731 glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PRIAM: Glutamate synthase (NADH); SPTR: Glutamate synthase, NADH/NADPH, small subunit; TIGRFAM: Glutamate synthase, NADH/NADPH, small subunit 1; IMG reference gene:2504770543; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthases, NADH/NADPH, small subunit. | COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006097:IPR006096; KEGG: rmr:Rmar_2129 Glu/Leu/Phe/Val dehydrogenase; PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region; Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; PRIAM: Glutamate dehydrogenase (NAD(P)(+)); SPTR: Glu/Leu/Phe/Val dehydrogenase; IMG reference gene:2504775708; PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.913 |
| AEE49079.1 | murI | Halhy_1182 | Halhy_3181 | Glutamate synthase, NADH/NADPH, small subunit; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR006005; KEGG: cpi:Cpin_0731 glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PRIAM: Glutamate synthase (NADH); SPTR: Glutamate synthase, NADH/NADPH, small subunit; TIGRFAM: Glutamate synthase, NADH/NADPH, small subunit 1; IMG reference gene:2504770543; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthases, NADH/NADPH, small subunit. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.800 |
| AEE49079.1 | purQ | Halhy_1182 | Halhy_4319 | Glutamate synthase, NADH/NADPH, small subunit; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR006005; KEGG: cpi:Cpin_0731 glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PRIAM: Glutamate synthase (NADH); SPTR: Glutamate synthase, NADH/NADPH, small subunit; TIGRFAM: Glutamate synthase, NADH/NADPH, small subunit 1; IMG reference gene:2504770543; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthases, NADH/NADPH, small subunit. | Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.900 |
| AEE49080.1 | AEE48314.1 | Halhy_1183 | Halhy_0403 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: chu:CHU_3776 glutamate synthase (NADH) large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (NADH) large subunit; IMG reference gene:2504770544; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: sli:Slin_5139 glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic region; SPTR: Glutamate--ammonia ligase; IMG reference gene:2504769758; PFAM: Glutamine synthetase, catalytic domain. | 0.958 |
| AEE49080.1 | AEE49079.1 | Halhy_1183 | Halhy_1182 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: chu:CHU_3776 glutamate synthase (NADH) large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (NADH) large subunit; IMG reference gene:2504770544; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | Glutamate synthase, NADH/NADPH, small subunit; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027:IPR006005; KEGG: cpi:Cpin_0731 glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PRIAM: Glutamate synthase (NADH); SPTR: Glutamate synthase, NADH/NADPH, small subunit; TIGRFAM: Glutamate synthase, NADH/NADPH, small subunit 1; IMG reference gene:2504770543; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthases, NADH/NADPH, small subunit. | 0.999 |
| AEE49080.1 | AEE52681.1 | Halhy_1183 | Halhy_4849 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: chu:CHU_3776 glutamate synthase (NADH) large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (NADH) large subunit; IMG reference gene:2504770544; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | Glutamate--ammonia ligase; COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146; KEGG: sli:Slin_2432 glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic region; Glutamine synthetase, beta-Grasp; PRIAM: Glutamate--ammonia ligase; SPTR: Glutamate--ammonia ligase; IMG reference gene:2504774244; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain. | 0.958 |
| AEE49080.1 | AEE54120.1 | Halhy_1183 | Halhy_6301 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: chu:CHU_3776 glutamate synthase (NADH) large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (NADH) large subunit; IMG reference gene:2504770544; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006097:IPR006096; KEGG: rmr:Rmar_2129 Glu/Leu/Phe/Val dehydrogenase; PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region; Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; PRIAM: Glutamate dehydrogenase (NAD(P)(+)); SPTR: Glu/Leu/Phe/Val dehydrogenase; IMG reference gene:2504775708; PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.985 |
| AEE49080.1 | murI | Halhy_1183 | Halhy_3181 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: chu:CHU_3776 glutamate synthase (NADH) large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (NADH) large subunit; IMG reference gene:2504770544; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.901 |
| AEE49080.1 | purQ | Halhy_1183 | Halhy_4319 | COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: chu:CHU_3776 glutamate synthase (NADH) large subunit; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (NADH) large subunit; IMG reference gene:2504770544; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. | Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.917 |
| AEE50607.1 | AEE51215.1 | Halhy_2739 | Halhy_3357 | COGs: COG0686 Alanine dehydrogenase; InterPro IPR007886:IPR007698; KEGG: cpi:Cpin_1259 alanine dehydrogenase; PFAM: Alanine dehydrogenase/PNT, C-terminal; Alanine dehydrogenase/PNT, N-terminal; PRIAM: Alanine dehydrogenase; SPTR: Alanine dehydrogenase; IMG reference gene:2504772110; PFAM: Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase/PNT, N-terminal domain; TIGRFAM: alanine dehydrogenase. | Alanine--glyoxylate transaminase; COGs: COG0160 4-aminobutyrate aminotransferase and related aminotransferase; InterPro IPR005814; KEGG: sus:Acid_7662 aminotransferase; PFAM: Aminotransferase class-III; PRIAM: Alanine--glyoxylate transaminase; SPTR: Aminotransferase; IMG reference gene:2504772737; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.903 |
